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Axin: A Master Scaffold for Multiple Signaling Pathways

Luo W. · Lin S.-C.

Author affiliations

Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, and Department of Biology, Xiamen University, Xiamen, China

Corresponding Author

Sheng-Cai Lin

Department of Biochemistry, Hong Kong University of Science and Technology

Clear Water Bay, Kowloon

Hong Kong (China)

Tel. +852 2358 7294, E-Mail linsc@ust.hk

Related Articles for ""

Neurosignals 2004;13:99–113

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Axin was originally identified from the characterization of the Fused locus, the disruption of which leads to duplication of axis and embryonic lethality. It is a multidomain protein that interacts with multiple proteins and functions as a negative regulator of Wnt signaling by downregulating the β-catenin levels. Recently, it was demonstrated that Axin also plays an important role in a JNK signaling pathway. Axin utilizes discriminatory domains for its distinct roles in the Wnt pathway and in the Axin/JNK pathway. Here we review the data that show how Axin regulates multiple signaling pathways by serving as a scaffold protein, controlling diverse cellular functions in proliferation, fate determination, and suppression of tumorigenesis.

© 2004 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Review

Received: September 05, 2003
Accepted: December 12, 2003
Published online: April 22, 2004
Issue release date: May – June

Number of Print Pages: 15
Number of Figures: 2
Number of Tables: 1

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

For additional information: http://www.karger.com/NSG

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