Frontotemporal Dementia: A Randomised, Controlled Trial with TrazodoneLebert F.a · Stekke W.b · Hasenbroekx C.c · Pasquier F.a
aMemory Clinic, Lille University Hospital, Lille, France; bPharmacia Laboratory, Diegem, cDepartment of Neurology, Heilig Hart Ziekenhuis, Roeselare, Belgium
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Behavioural troubles due to frontotemporal dementia (FTD) are difficult to treat. The serotonergic system is associated with frontal lobes, the degeneration of which contributes to FTD. Trazodone increases the extracellular 5-HT levels in the frontal cortex. In a randomised, double-blind, placebo-controlled cross-over study, we investigated the effect of trazodone. There was a significant decrease in the Neuropsychiatry Inventory (NPI) total score with trazodone (p = 0.028) in the 26 evaluable patients. A decrease of more than 50% in the NPI score was observed in 10 patients with trazodone. This improvement was mainly based on the improvement of 4 items of the scale (irritability, agitation, depressive symptoms and eating disorders). The Mini-Mental State Examination was not modified and trazodone was well tolerated. Results of this first placebo-controlled trial suggest that trazodone is an effective treatment for the behavioural symptoms of FTD.
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Grossman MA: Multidisciplinary approach to Pick’s disease and frontotemporal dementia. Neurology 2001;56:1S–2S.
- Sjögren M, Minthon L, Passant U, et al: Decreased monoamine metabolites in frontotemporal dementia and Alzheimer’s disease. Neurobiol Aging 1998;19:379–384.
- Sparks DL, Markesbery WR: Altered serotonergic and cholinergic synaptic markers in Pick’s disease. Arch Neurol 1991;48:796–799.
Procter AW, Qurne M, Francis PT: Neurochemical features of frontotemporal dementia. Dement Geriatr Cogn Disord 1999;10(suppl 1):80–84.
- Swartz JR, Miller BL, Lesser IM, Darby AL: Frontotemporal dementia: Treatment response to serotonin selective reuptake inhibitors. J Clin Psychiatry 1997;58:212–216.
Lebert F, Pasquier F, Petit H: Trazodone in the treatment of behavior in frontotemporal dementia. Hum Psychopharmacol Clin Exp 1999;14:279–281.
- Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gorbein J: The neuropsychiatric inventory. Neurology 1994;44:2308–2314.
- Lebert F, Pasquier F, Souliez L, Petit H: Frontotemporal behavioral scale. Alzheimer Dis Assoc Disord 1998;12:335–339.
Mattis S: Mental status examination for organic mental syndrome in the elderly patients; in Bellak L, Karasu TB (eds): Geriatric Psychiatry. New York, Grune & Stratton, 1986, pp 77–121.
- Folstein MF, Folstein SE, McHugh PR: ‘Mini-mental state’: A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–198.
- Teri L, Logsdon RG, Peskind E, et al: Treatment of agitation in AD: A randomized, placebo-controlled clinical trial. Neurology 2000;55:1271–1278.
Pasquier F, Fukui I, Sarazin M, et al: Laboratory investigations and treatment. Ann Neurol 2003;53(suppl 5):S32–S35.
Chow TW: Frontotemporal dementias: Clinical features and management. Semin Clin Neuropsychiatry 2003, 8:58–70.
- Moretti R, Torre P, Antonello RM, Cazzato G, Bava A: Frontotemporal dementia: Paroxetine as a possible treatment of behavior symptoms. Eur Neurol 2003;49:13–19.
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