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Biological Psychiatry. Editor: J. Mendlewicz (Brussels). Original Paper

Association between Norepinephrine Transporter Gene Polymorphism and Major Depression

Ryu S.-H.a · Lee S.-H.b · Lee H.-J.c · Cha J.-H.c · Ham B.-J.c · Han C.-S.c · Choi M.-J.c · Lee M.-S.c

Author affiliations

aDepartment of Psychiatry, Konkuk University College of Medicine, bDepartment of Psychiatry, Inje University College of Medicine, and cDepartment of Psychiatry, Korea University College of Medicine, Seoul, Korea

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Neuropsychobiology 2004;49:174–177

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels). Original Paper

Published online: May 06, 2004
Issue release date: May 2004

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

Noradrenergic and serotonergic abnormalities have long been implicated in patients with major depression. The novel selective norepinephrine reuptake inhibitor reboxetine has been shown to be at least as effective as imipramine, desipramine and fluoxetine in the treatment of major depression. It is suggested that the dysfunction of the norepinephrine transporter (NET) may be related to major depression. Although the transcriptional activity related to the NET gene expression is little known, it may be a good candidate gene for major depression. Therefore, we investigated whether the T-182C polymorphism of the NET gene is associated with major depression in a Korean sample of 112 major depression patients compared with 136 healthy controls. We found a significantly lower frequency in TT genotype in patients with major depression than in normal controls when the genotypes of T-182C polymorphism were classified into two groups: TT group versus TC + CC group (p = 0.019). This result suggests that the T-182C polymorphism in the NET gene might be associated with major depression.

© 2004 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels). Original Paper

Published online: May 06, 2004
Issue release date: May 2004

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS


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