Neuropsychobiology

Pharmacopsychiatry. Editor: B. Saletu (Vienna). Original Paper

Quetiapine Treatment for Behavioral and Psychological Symptoms in Patients with Senile Dementia of Alzheimer Type

Fujikawa T.a · Takahashi T.a · Kinoshita A.a · Kajiyama H.a · Kurata A.a · Yamashita H.b · Yamawaki S.b

Author affiliations

aDepartment of Psychiatry, National Sanatorium Kamo Hospital, and bDepartment of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Hiroshima, Japan

Keywords: Behavioral and psychological symptoms of dementiaSenile dementia of Alzheimer typeExtrapyramidal symptomsQuetiapineRisperidoneOlanzapine

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Neuropsychobiology 2004;49:201–204
https://doi.org/10.1159/000077367

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Article / Publication Details

First-Page Preview
Abstract of Pharmacopsychiatry. Editor: B. Saletu (Vienna). Original Paper

Published online: May 06, 2004
Issue release date: May 2004

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

The purpose of this study was to assess the effect of quetiapine in the treatment of behavioral and psychological symptoms of dementia (BPSD) in patients with senile dementia of Alzheimer type (SDAT). Sixteen SDAT patients with BPSD were recruited and quetiapine (25– 200 mg/day) was prescribed for 8 weeks. BPSD were evaluated with the Behavioral Pathology in Alzheimer’s Disease Rating Scale (BEHAVE-AD) and Cohen-Mansfield Agitation Inventory (CMAI) at week 0 (baseline) and week 8 (endpoint). The severity of the extrapyramidal symptoms was also assessed by the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS) at baseline and endpoint. Significant improvements were seen in the CMAI total score and in the BEHAVE-AD subscales of delusions, activity disturbances, aggressiveness, diurnal rhythm disturbances and in the BEHAVE-AD overall severity. There was no significant difference between the baseline and endpoint in the DIEPSS score. These data indicate that quetiapine is effective in controlling BPSD with favorable adverse-event profiles.

© 2004 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Pharmacopsychiatry. Editor: B. Saletu (Vienna). Original Paper

Published online: May 06, 2004
Issue release date: May 2004

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

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2004, Vol.49, No. 4

May 2004

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