Acta Haematologica
Case Report
T Cell Receptor δ-Chain Gene Rearrangement in a Novel Case of Adult NK Cell LeukemiaStagno F.a · Guglielmo P.a · Lo Nigro L.b · Santonocito A.a · Giustolisi R.aaChair of Hematology, and bPediatric Hematology, University of Catania, Catania, Italy
Keywords: NK leukemiaT cell receptorAcute leukemia |
|
Acta Haematol 2004;111:225–227
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
* The final prices may differ from the prices shown due to specifics of VAT rules.
Article / Publication Details
First-Page Preview
Received: July 21, 2003
Accepted: December 16, 2003
Published online: May 18, 2004
Issue release date: May 2004
Number of Print Pages: 3
Number of Figures: 1
Number of Tables: 0
ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)
For additional information: https://www.karger.com/AHA
Abstract
Malignancies arising from natural killer (NK) cells are being increasingly recognized as distinct clinicopathological entities. We here report the characteristics of a peculiar case of NK-cell acute leukemia with unusual agranular morphology and rearrangement of the T-cell receptor (TCR) δ-chain gene.
© 2004 S. Karger AG, Basel
Related Articles:
References
- Ortaldo JR, Winkler-Pickett RT, Yagita H, Young HA: Comparative studies of CD3– and CD3+ CD56+ cells: Examination of morphology, functions, T cell receptor rearrangement and pore-forming protein expression. Cell Immunol 1991;136:486–495.
- Robertson MJ, Ritz J: Biology and clinical relevance of human natural killer cells. Blood 1990;76:2421–2438.
-
Greer JP, Kinney MC, Loughran TP Jr: T cell and NK cell lymphoproliferative disorders; in ASH Education Program Book. Hematology 2001;259–281.
- Loughran TP Jr: Clonal diseases of large granular lymphocytes. Blood 1993;82:1–14.
- Langerak AW, Szczepanski T, van der Burg M, Wolvers-Tettero ILM, van Dongen JJM: Heteroduplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations. Leukemia 1997;11:2192–2199.
- Chan DW, Liang R, Kwong YL: Pattern of T cell receptor delta gene rearrangement by Southern blotting and polymerase chain reaction technique in Hong Kong Chinese patients with non-T cell hematological malignancies. Hematol Oncol 1996;14:57–66.
- Schmidt CA, Oettle H, Neubauer A, Seeger K, Thiel E, Huhn D, Siegert W, Ludwig WD: Rearrangements of T cell receptor delta, gamma and beta genes in acute myeloid leukemia coexpressing T-lymphoid features. Leukemia 1992;6:1263–1267.
- Nagano M, Kimura N, Akiyoshi T, Nishimura J, Kozuru M, Okamura J, Katsuno M, Yoshida T, Takeshita M, Tachibana K, Ohshima K, Kikuchi M: T-stem cell leukemia/lymphoma with both myeloid lineage conversion and T-specific delta recombination. Leuk Res 1997;21:763–773.
-
Raulet DH, Garman RD, Saito M, Tonegawa S: Developmental regulation of T cell receptor gene expression. Nature 1985:314;103–107.
- Lefranc MP, Rabbitts TH: Two tandemly organized human genes encoding the T cell γ constant-region sequences show multiple rearrangement in different T cell types. Nature 1985;316:464–466.
- Brody JP, Allen S, Schulman P, Sun T, Chan WC, Friedman HD, Teichberg S, Koduru P, Cone RW, Loughran TP Jr: Acute agranular CD4-positive natural killer cell leukemia. Comprehensive clinicopathologic studies including virologic and in vitro culture with inducing agents. Cancer 1995;75:2474–2483.
- Kobayashi Y, Uehara S, Inamori K, Shirato R, Ozawa K, Sklar J, Asano S: Hemophagocytosis as a para-neoplastic syndrome in NK cell leukemia. Int J Hematol 1996;64:135–142.
- Imamura N, Kusunoki Y, Kawa-Ha K, Yumura K, Hara J, Oda K, Abe K, Dohy H, Inada T, Kajihara H, Kuramoto A: Aggressive natural killer cells leukemia/lymphoma: report of four cases and review of the literature. Possible existence of a new clinical entity originating from the third lineage of lymphoid cells. Br J Haematol 1990;75:49–59.
- Suzuki R, Yamamoto K, Seto M, Kagami Y, Ogura M, Yatabe Y, Suchi T, Kodera Y, Morishima Y, Takahashi T, Saito H, Ueda R, Nakamura S: CD7+ and CD56+ myeloid/natural killer cell precursor acute leukemia: A distinct hematolymphoid disease entity. Blood 1997;90:2417–2428.
- Yoshida T, Kimura N, Sawada H, Suematsu E, Nagano M, Akiyoshi T, Motomura S, Kikuchi M, Nishimura J, Tamura K: CD56+CD7+ stem cell leukemia/lymphoma with D2-Jdelta1 rearrangement. Intern Med 1999;38:547–555.
- Suzuki R: Malignancies of natural killer (NK) cell precursor: Myeloid/NK cell precursor acute leukemia and blastic NK cell lymphoma/leukemia. Leuk Res 1999;23:615–624.
- Kwong YL, Chan AC, Liang RH: Natural killer cell lymphoma/leukemia: Pathology and treatment. Hematol Oncol 1997;15:71–79.
- Sanchez MJ, Muench MO, Roncarolo MG, Lanier LL, Phillips JH: Identification of a common T/natural killer cell progenitor in human fetal thymus. J Exp Med 1994;180:569–576.
Article / Publication Details
First-Page Preview
Received: July 21, 2003
Accepted: December 16, 2003
Published online: May 18, 2004
Issue release date: May 2004
Number of Print Pages: 3
Number of Figures: 1
Number of Tables: 0
ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)
For additional information: https://www.karger.com/AHA
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Get Permission
PubMed ID
