Original Research Article
Region-Specific Decline of Cerebral Glucose Metabolism in Patients with Frontotemporal Dementia: A Prospective 18F-FDG-PET StudyGrimmer T.a · Diehl J.a · Drzezga A.b · Förstl H.a · Kurz A.a
Departments of aPsychiatry and Psychotherapy, bNuclear Medicine, Technical University Munich, Munich, Germany
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Objective: The aim of this study was to examine the pattern of glucose uptake and the changes over time of metabolic deficits in patients with frontotemporal dementia (FTD). Methods: 10 patients who had received the clinical diagnosis of FTD underwent positron emission tomography scanning at the time of their first examination (baseline) and at follow-up (after 17.1 ± 6.0 months). For statistical analysis, we used the SPM 99 software. First, we compared the data of the patients at baseline with an age-matched healthy control group. Second, we compared glucose uptake at follow-up with baseline measurements. Results: Compared with normal controls, FTD patients showed significant metabolic deficits primarily in frontal cortical areas, but also in the caudate nuclei and the thalami. At follow-up, a significant progression of metabolic deficit was exclusively observed in the orbitofrontal parts of the frontal lobe and in the subcortical structures. Discussion: These findings demonstrate that the clinical progression in patients with FTD is accompanied by a region-specific decline in cerebral glucose metabolism.
© 2004 S. Karger AG, Basel
- Hodges J, Miller B: The classification, genetics and neuropathology of frontotemporal dementia. Introduction to the special topic papers. Part 1. Neurocase 2001;7:31–35.
- Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert PH, Albert M, Boone K, Miller BL, Cummings J, Benson DF: Frontotemporal lobar degeneration. A consensus on clinical diagnostic criteria. Neurology 1998;51:1546–1554.
- Rosen H, Hartikainen K, Jagust W, Kramer J, Reed B, Cummings J, Boone K, Ellis W, Miller C, Miller B: Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD. Neurology 2002;58:1608–1614.
- Chan D, Fox N, Scahill R, et al: Patterns of temporal lobe atrophy in semantic dementia and Alzheimer’s disease. Ann Neurol 2001;49:433–442.
- Galton C, Patterson K, Graham K, Lambon-Ralph M, William G, Antoun N, Sahakian B, Hodges J: Differing patterns of temporal atrophy in Alzheimer’s disease and semantic dementia. Neurology 2001;57:216–225.
- Herholz K, Salmon E, Perani D, Baron JC, Holthoff V, Frolich L, Schonknecht P, Ito K, Mielke R, Kalbe E, Zundorf G, Delbeuck X, Pelati O, Anchisi D, Fazio F, Kerrouche N, Desgranges B, Eustache F, Beuthien-Baumann B, Menzel C, Schroder J, Kato T, Arahata Y, Henze M, Heiss WD: Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage 2002;17:302–316.
- Kamo H, McGeer P, Harrop R, et al: Positron emission tomography and histopathology in Pick’s disease. Neurology 1987;37:439–445.
- Ishii K, Sakamato S, Sasaki M, Kitagaki H, Yamaji S, Hashimoto M, Imamura T, Hirono N, Mori E: Cerebral glucose metabolism in patients with frontotemporal dementia. J Nucl Med 1998;39:1875–1878.
- Michotte A, Goldman S, Tugendhaft P, Zegers de Beyl D: Frontotemporal dementia: A clinical-pathological study. Acta Neurol Belg 2001;101:224–229.
- The Lund and Manchester Groups: Clinical and neuropathological criteria for frontotemporal dementia. J Neurol Neurosurg Psychiatry 1994;57:416–418.
- McKhann G, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 1984;34:939–944.
- Reading P, Luce A, McKeith I: Rivastigmine in the treatment of Parkinsonian hallucinosis (abstract). Mov Disord 2001;16:1171–1174.
- Román GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Maseu JC, Garcia JH, Amaducci L, Orgogozo JM, Brun A, Hofman A, Moody DM, O’Brien MD, Yamaguchi T, Grafman J, Drayer BP, Bennet DA, Fisher M, Ogata J, Kokmen E, Bermejo F, Wolf PA, Gorelick PB, Bick KL, Pajeau AK, Bell MA, DeCarli C, Culebras A, Korczyn AD, Bogousslavsky J, Hartmann A, Scheinberg P: Vascular dementia: Diagnostic criteria for research studies: Report of the NINDS-AIREN International Workshop. Neurology 1993;43:250–260.
Thalmann B, Monsch AU: CERAD. The Consortium to Establish a Registry for Alzheimer’s Disease. Neuropsychologische Testbatterie. Basel, Memory Clinic Basel, 1997.
- Minoshima S, Frey KA, Koeppe RA, Foster NL, Kuhl DE: A diagnostic approach in Alzheimer’s disase using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. J Nucl Med 1995;36:1238–1248.
- Brun A, Passant U: Frontal lobe degeneration of non-Alzheimer type. Structural characteristics, diagnostic criteria and relation to other frontotemporal dementias. Acta Neurol Scand Suppl 1996;168:28–30.
Morris J: Pick’s disease; in Morris MM, Esiri JH (eds): The Neuropathology of Dementia. Cambridge, Cambridge University Pres, 1997, pp 204–213.
- Brun A: Frontal lobe degeneration of non-Alzheimer type revisited. Dementia 1993;4:126–131.
- Knopman DS, Mastri AR, Frey WH, Sung JH, Rustan T: Dementia lacking distinctive histologic features: A common non-Alzheimer degenerative dementia. Neurology 1990;40:251–256.
- Cummings J: Frontal-subcortical circuits and human behavior. Arch Neurol 1993;50:873–880.
- Garraux G, Salmon E, Degueldre C, Lemaire C, Laureys S, Franck G: Comparison of impaired subcortico-frontal metabolic networks in normal aging, subcortico-frontal dementia, and cortical frontal dementia. Neuroimage 1999;10:149–162.
- Dauth G, Gilman S, Frey KA, Penney JB Jr: Basal ganglia glucose utilization after recent precentral ablation in the monkey. Ann Neurol 1985;17:431–438.
- Sultzer DL, Mahler ME, Cummings JL, VanGorp WG, Hinkin CH, Brown C: Cortical abnormalities associated with subcortical lesions in vascular dementia. Arch Neurol 1995;52:773–780.
- Han L, Cole M, Bellavance F, McCusker J, Primeau F: Tracking cognitive decline in Alzheimer’s disease using the mini-mental state examination: A meta-analysis. Int Psychogeriatr 2000;12:231–247.
- Pietrini P, Guazzelli M, Basso G, Jaffe K, Grafman J: Neural correlates of imaginal aggressive behavior assessed by positron emission tomography in healthy subjects. Am J Psychiatry 2000;157:1772–1781.
- Diehl J, Kurz A: Frontotemporal dementia: Patient characteristics, cognition, and behaviour. Int J Geriatr Psychiatry 2002;17:914–918.
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.