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Original Research Article

Region-Specific Decline of Cerebral Glucose Metabolism in Patients with Frontotemporal Dementia: A Prospective 18F-FDG-PET Study

Grimmer T.a · Diehl J.a · Drzezga A.b · Förstl H.a · Kurz A.a

Author affiliations

Departments of aPsychiatry and Psychotherapy, bNuclear Medicine, Technical University Munich, Munich, Germany

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Dement Geriatr Cogn Disord 2004;18:32–36

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: September 23, 2003
Published online: June 17, 2004
Issue release date: June 2004

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

Objective: The aim of this study was to examine the pattern of glucose uptake and the changes over time of metabolic deficits in patients with frontotemporal dementia (FTD). Methods: 10 patients who had received the clinical diagnosis of FTD underwent positron emission tomography scanning at the time of their first examination (baseline) and at follow-up (after 17.1 ± 6.0 months). For statistical analysis, we used the SPM 99 software. First, we compared the data of the patients at baseline with an age-matched healthy control group. Second, we compared glucose uptake at follow-up with baseline measurements. Results: Compared with normal controls, FTD patients showed significant metabolic deficits primarily in frontal cortical areas, but also in the caudate nuclei and the thalami. At follow-up, a significant progression of metabolic deficit was exclusively observed in the orbitofrontal parts of the frontal lobe and in the subcortical structures. Discussion: These findings demonstrate that the clinical progression in patients with FTD is accompanied by a region-specific decline in cerebral glucose metabolism.

© 2004 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: September 23, 2003
Published online: June 17, 2004
Issue release date: June 2004

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM


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