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Original Research Article

Hallucinations Predict Attentional Improvements with Rivastigmine in Dementia with Lewy Bodies

McKeith I.G.a · Wesnes K.A.b · Perry E.a · Ferrara R.c

Author affiliations

aInstitute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, and bCognitive Drug Research Ltd., Reading, UK; cNovartis Pharma SpA, Origgio, Italy

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Dement Geriatr Cogn Disord 2004;18:94–100

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: November 07, 2003
Published online: June 17, 2004
Issue release date: June 2004

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

The aim of this analysis of the effects of cholinergic therapy in dementia with Lewy bodies was to determine whether rivastigmine-induced benefits in attention and memory could be predicted by the presence of visual hallucinations. At study entry, 74% of patients were hallucinators and 26% were non-hallucinators. The population was analyzed for two-factor scores: power of attention (PoA) and quality of memory (QoM). A significant effect over placebo on PoA was observed in hallucinators at weeks 12 (p = 0.023) and 20 (p = 0.0019), while no treatment effects were seen in non-hallucinators. Significant treatment effects on QoM were not observed in either subgroup. Visual hallucinations predicted greater improvements in PoA, but not QoM. This may reflect the greater cholinergic deficits in areas of the brain responsible for visual hallucinations, offering greater potential for attentional improvement.

© 2004 S. Karger AG, Basel


References

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    External Resources
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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: November 07, 2003
Published online: June 17, 2004
Issue release date: June 2004

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM


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