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Biological Psychiatry. Editor: J. Mendlewicz (Brussels). Original Paper

Decreased Plasma Antioxidants in Schizophrenia

Pae C.-U. · Paik I.-H. · Lee C. · Lee S.-J. · Kim J.-J. · Lee C.-U.

Author affiliations

Department of Psychiatry, Kangnam St. Mary’s Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea

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Neuropsychobiology 2004;50:54–56

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels). Original Paper

Published online: June 11, 2004
Issue release date: June 2004

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

An aberration in the level of antioxidants has been suggested in schizophrenia. Therefore, this study examined the difference in the antioxidant level between patients with schizophrenia and healthy controls, as well as the difference between the drug-naïve schizophrenic patients with a first episode (FSPR) and the risperidone-treated chronic schizophrenia (RCSPR) patients. The plasma albumin, bilirubin and uric acid levels were determined in 47 FSPR and 55 chronic schizophrenia patients who met the DSM-IV criteria for schizophrenia, and in 68 controls. The albumin and bilirubin levels were significantly lower in the schizophrenic patients compared to the controls, although there was no significant difference between the FSPR and RCSPR patients. The bilirubin level was significantly lower in the negative subgroup of the patient group. This study supports the hypothesis that an aberration in the antioxidant levels may be involved in schizophrenia. In addition, this study suggests that the antioxidant level may be associated with the clinical symptomatology as well as the treatment implications in schizophrenia, particularly the negative symptoms.

© 2004 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels). Original Paper

Published online: June 11, 2004
Issue release date: June 2004

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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