SARS in Newborns and ChildrenNg P.C.a · Leung C.W.b · Chiu W.K.c · Wong S.F.d · Hon E.K.L.a
aDepartment of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, bDepartment of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, cDepartment of Paediatrics and Adolescent Medicine, UnitedChristian Hospital, Hong Kong, and dDepartment of Obstetrics and Gynaecology, Princess Margaret Hospital, Hong Kong
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The severe acute respiratory syndrome (SARS) is a highly contagious infection caused by a newly discovered strain of coronavirus (SARS-CoV). Infants born to pregnant women with SARS did not appear to acquire the infection through vertical transmission. Some newborn infants, however, developed severe intrauterine growth retardation and life-threatening gastrointestinal complications. It is now known that the clinical course and prognosis are different between paediatric and adult SARS patients. Young children (<12 years), in general, run a less aggressive clinical course than do teenage and adult patients. Thus far, no fatalities have been reported in the paediatric age group (≤18 years). This review describes the current understanding of the clinical manifestations, diagnostic tests, immunological profiles, patient management and outcomes of SARS-CoV infection in the paediatric population.
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