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Genomics Technologies and Diseases

Genetic modifiers in mice: the example of the fragile X mouse model

Errijgers V. · Kooy R.F.

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Department of Medical Genetics, University of Antwerp, Antwerp (Belgium)

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Cytogenet Genome Res 105:448–454 (2004)

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Article / Publication Details

First-Page Preview
Abstract of Genomics Technologies and Diseases

Published online: July 14, 2004
Issue release date: June 2004

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

Abstract

Modifiers play an important role in most, if not all human diseases, and mouse models. For some disease models, such as the cystic fibrosis knockout mouse model, the effect of genetic factors other than the causative mutation has been well established and a modifier gene has been mapped. For other mouse models, including those of the fragile X syndrome, a common form of inherited mental retardation, controversies between test results obtained in different laboratories have been well recognized. Yet, the possibility that modifiers could at least explain part of the discrepancies is only scarcely mentioned. In this review we compare the test results obtained in different laboratories and provide evidence that modifiers may affect disease severity in the fragile X knockout mouse.   

© 2004 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Genomics Technologies and Diseases

Published online: July 14, 2004
Issue release date: June 2004

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR


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