Clinical and Laboratory Investigations
Family History and Risk of Hair LossChumlea W.C.a · Rhodes T.b · Girman C.J.b · Johnson-Levonas A.c · Lilly F.R.W.d · Wu R.a · Guo S.S.a
aDepartment of Community Health, Wright State University School of Medicine, Dayton, Ohio, bDepartment of Epidemiology, Merck Research Laboratories, West Point, Pa., cDepartment of Endocrinology and Metabolism, Merck Research Laboratories, Rahway, N.J., and dDepartment of Community Planning, Hanover Hospital, Hanover, Pa., USA
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Article / Publication Details
Introduction: The genetic basis of androgenetic alopecia (AGA) is well accepted in the medical community and among the general population. However, rigorous studies investigating the familial basis of AGA are lacking. The purpose of the current study was to explore the relationship between family history and expression of AGA in a sample of men from the general community. Methods: Hair loss was assessed by an independent observer trained by an expert dermatologist using the Norwood/Hamilton classification scale and a 7-point global description of hair loss. Men were classified into two groups, one as having little or no hair loss and the other having hair loss. The family history of hair loss in parents and grandparents was assessed by subject self-report. Results: Adjusting for age, men whose fathers had hair loss were 2.5 times as likely to have had some level of hair loss compared to men whose fathers had no hair loss (95% CI: 1.3–4.9). Likewise, men whose fathers had hair loss were twice as likely to have hair loss than men whose fathers had no hair loss even after adjusting for age (OR = 2.1, 95% CI: 1.2–3.7 and OR = 2.5, 95% CI: 1.4–4.7 for Norwood/Hamilton and global description of hair loss assessments, respectively). Conclusion: Results suggest that the probability of male pattern hair loss is dependent on family history and age. Hair loss in a man’s father also appears to play an important role in increasing a man’s risk of hair loss, either in conjunction with a history of hair loss in the mother or hair loss in the maternal grandfather.
© 2004 S. Karger AG, Basel
Hamilton JB: Male hormone stimulation is a prerequisite and an incitant in common baldness. Am J Anat 1942;71:451–480.
- Norwood O: Male pattern baldness: Classification and incidence. South Med J 1975;68:1359–1365.
- Hamilton JB: Patterned loss of hair in man: Types and incidence. Ann NY Acad Sci 1951;53:708–728.
Bergfeld WF: Androgenetic alopecia: An autosomal dominant disorder. Am J Med 1995;98(suppl 1A):95S–98S.
Osborn D: Inheritance of baldness. J Hered 1916;7:347–355.
- Ellis JA, Stebbing M, Harrap SB: Genetic analysis of male pattern baldness and the 5α-reductase genes. J Invest Dermatol 1998;110:849–853.
- Kuster W, Happle R: The inheritance of baldness: Two B or not two B? J Am Acad Dermatol 1984;11:921–926.
- Hoffmann R, Happle R: Current understanding of androgenetic alopecia. I. Etiopathogenesis. Eur J Dermatol 2000;10:319–326.
- Konig A, Happle R, Tchitcherina ES Jr, Sokolowski P, Kohler W, Hoffman R: An X-linked gene involved in androgenetic alopecia: A lesson to be learned from adrenoleukodystrophy. Dermatology 2000;200:213–218.
- Ellis JA, Stebbing M, Harrap SB: Polymorphism of the androgen receptor gene is associated with male pattern baldness. J Invest Dermatol 2001;116:452–455.
- Wilson PW, Kannel WB: Is baldness bad for the heart? JAMA 1993;269:1035–1036.
- Trevisan M, Farinaro E, Krogh V, Jossa F, Giumetti D, Fusco G, Panico S, Mellone C, Frascatore S, Scottoni A, et al: Baldness and coronary heart disease risk factors. J Clin Epidemiol 1993;46:1213–1218.
- Ford ES, Freedman, DS, Byers T: Baldness and ischemic heart disease in a national sample of men. Am J Epidemiol 1996;143:651–657.
- Oh BR, Kim SJ, Moon JD, Kim HN, Kwon DD, Won YH, Ryu SB, Park YI: Association of benign prostatic hyperplasia with male pattern baldness. Urology 1998;51:744–748.
Hawk E, Breslow RA, Graubard BI: Male pattern baldness and clinical prostate cancer in the epidemiologic follow-up of the first National Health and Nutrition Examination Survey. Cancer Epidemiol Biomarkers Prev 2000;9:523–527.
- Girman CJ, Rhodes T, Guo S, Lilly FRW, Siervogel RM, Patrick DL, Chumlea WC: Effects of self-perceived hair loss in a community sample of men. Dermatology 1998;197:223–229.
- Rhodes T, Girman CJ, Savin RC, Kaufman KD, Guo SS, Lilly FRW, Siervogel RM, Chumlea WC: Prevalence of male pattern hair loss in 18–49 year old men. Dermatol Surg 1998;24:1330–1332.
Barber BL, Kaufman KD, Kozloff RC, Girman CJ, Guess HA: A hair growth questionnaire for use in the evaluation of therapeutic effects in men. J Dermatol Treat 1989;9:181–186.
Lilly FRW, Chumlea WC, Guo S, Rhodes T, Girman CJ: Interrater agreement of rater and subject assessments of male pattern hair loss (abstract). J Invest Dermatol 1998;110:199.
- Van der Donk MA, Passchier J, Dutree-Meulenberg ROGM, Stolz E, Verhage F: Psychological characteristics of men with alopecia androgenetica and their modification. Int J Dermatol 1991;30:22–28.
- Cash TF, Price VH, Savin RC: Psychological effects of androgenetic alopecia on women: Comparisons with balding men and with female control subjects. J Am Acad Dermatol 1993;29:568–575.
- Cash TF: The psychological effects of androgenetic alopecia in men. J Am Acad Dermatol 1992;26:926–931.
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.