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Original Paper

Coexistence of IgE-Mediated Allergy and Type 1 Diabetes in Childhood

Caffarelli C.a · Cavagni G.b · Pierdomenico R.c · Chiari G.a · Spattini A.b · Vanelli M.a

Author affiliations

aDipartimento dell’Età Evolutiva, Clinica Pediatrica, Parma, bAzienda Unità Sanitaria Locale Modena Sud, Modena, and cAzienda Unità Sanitaria Locale Ascoli Piceno, Ascoli Piceno, Italy

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Int Arch Allergy Immunol 2004;134:288–294

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 15, 2003
Accepted: April 28, 2004
Published online: August 05, 2004
Issue release date: August 2004

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA

Abstract

Background: Autoimmune disorders are considered to be associated with a Th1 immune response while allergic diseases with a Th2 response. We carried out a study to determine whether there is an inverse relationship between allergic diseases in IgE-sensitized children or positive skin-prick test reactions to allergens and type 1 diabetes mellitus (DM1) in children. Methods: Sixty-three children with DM1 and 108 controls were enrolled. Parents of all children compiled a questionnaire on allergic diseases. All children underwent skin-prick tests for common aero-allergens and food-allergens. Results: A history of allergic symptoms, especially wheezing, asthma and allergic rhinitis was significantly less common in the group with DM1. Allergic symptoms in children with IgE sensitization or parental atopy were no more likely in children with DM1 than in normal control subjects. There was no association between skin-prick test results to inhalants and food allergens and DM1. Conclusions: Consistently with the Th1/Th2 paradigm, we observed a reduction in the frequency of allergic symptoms in children with DM1. However, our study did not succeed in demonstrating an inverse relation between Th1- and Th2-mediated diseases in children with IgE sensitization or an atopic genetic predisposition.

© 2004 S. Karger AG, Basel


References

  1. Holt PG, Jones CA: The immunology of fetuses and infants. The development of the immune system during pregnancy and early life. Allergy 2000;5:619–625.
  2. Johansson SGO, O’B Hourihane J, Bousquet J, Bruijnzel-Koomen, Dreborg S, Haahtela T, Kowalski ML, Mygind N, Ring J, van Cauwenberge P, van Hage-Hamsten M, Wuthrich B: A revised nomenclature for allergy. Allergy 2001;56:813–824.
  3. Prescott SL, Macaubas C, SmallacombeT, Holt BJ, Sly PD, Holt PG: Development of allergen-specificT-cell memory in atopic and normal children. Lancet 1999;353:196–200.
  4. Martinez FD, Stern DA, Wright AL, Holberg CJ, Taussig LM, Halonen M: Association of interleukin-2 and interferon-c production by blood mononuclear cells in infancy with parental allergy skin tests and with subsequent development of atopy. J Allergy Clin Immunol 1995;96:652–660.
  5. Chakir J, Laviolette M, Turcotte H, Boutet M, Boulet LP: Cytokine expression in the lower airways of nonasthmatic subjects with allergic rhinitis: Influence of natural allergen exposure. J Allergy Clin Immunol 2000;106:904–910.
  6. Faust A, Rothe H, Schade U, Lampeter E, Kolb H: Primary nonfunction of islet grafts in autoimmune diabetic nonobese diabetic mice is prevented by treatment with interleukin-4 and interleukin-10. Transplantation 1996;62:648–652.
  7. The EURODIAB ACE substudy 2 group: Decreased prevalence of atopic diseases in children with diabetes. J Pediatr 2000;137:470–474.
  8. Olesen AB, Birkebaek N, Therstrup-Pedersen K: Association between atopic dermatitis and insulin-dependent diabetes mellitus: A case-control study. Lancet 2001;357:1749–1752.
  9. Rosenbauer J, Herzig P, Giani G: Atopic eczema in early childhood could be protective against type 1 diabetes. Diabetologica 2003;46:784–788.
  10. Douek IF, Leech NJ, Gillmor HA, Bingley PJ, Gale EAM: Children with type-1 diabetes and their unaffected siblings have fewer symptoms of asthma. Lancet 1999;353:1850.
  11. Sheikh A, Smeeth L, Hubbard R: There is no evidence of an inverse relationship between Th2-mediated atopy and TH1-mediated autoimmune disorders: Lack of support for the hygiene hypothesis. J Allergy Clin Immunol 2003;111:131–135.
  12. Stromberg G, Ludvigsson GJ, Bjorksten B: Atopic disease and delayed hypersensitivity in children with diabetes. J Allergy Clin Immunol 1995;96:188–192.
  13. Kauppi P, Laitinen LA, Laitinen H, Kere J, Laitinen T: Verification of self-reported asthma and allergy in subjects and their family members volunteering for gene mapping studies. Respir Med 1998;92:1281–1288.
  14. Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, Mitchell EA, Pearce N, Sibbald B, Stewart AW, Strachan D, Weiland SK, Williams HC: International study of asthma and allergies in childhood (ISAAC): Rationale and methods. Eur Respir J 1995;8:483–491.
  15. Mattila PS, Tarkanne J, Saxen H, Pitkaniemi J, Karvonen M, Tuomilehto J and the DIME Study Group: Predisposition to atopic symptoms to inhaled antigens may protect from childhood type 1 diabetes. Diabetes Care 2002;25:865–868.
  16. Platschke PP, Janson C, Norrman E, Bjornsson E, Ellbjar S, Jarvholm B: Onset and remission of allergic rhinitis and asthma and the relationship with atopic sensitization and smoking. Am J Respir Crit Care Med 2000;162:920–924.
  17. Bettiol L, Bartsch P, Louis R, de Groote D, Gevaerts Y, Louis E, Malaise M: Cytokine production from peripheral whole blood in atopic and nonatopic asthmatics: relationship with blood and sputum eosinophilia and serum IgE levels. Allergy 2000;55:1134–1141.
  18. Hill DJ, Shelton MJ, Hosking CS: Predicting the results of allergen bronchial challenge by simple clinical methods. Clin Allergy 1982;12:295–301.
  19. Tresch S, Holzmann D, Baumann S, Blaserz K, Wuthrich B, Crameriz R, Schmid-Grendelmeierz P: In vitro and in vivo allergenicity of recombinant Bet v 1 compared to the reactivity of natural birch pollen extract. Clin Exp Allergy 2003;33:1153–1158.
  20. Host A, Halken S: Practical aspects of allergy-testing. Paediatr Respir Rev 2003;4:312–318.
  21. Strachan DP: Family size, infection and atopy: The first decade of the ‘hygiene hypothesis’. Thorax 2000;55:S2–S10.
  22. Simpson CR, Anderson WJA, Helms PJ, Taylor MW, Watson L, Prescott GJ, Godden DJ: Coincidence of immune-mediated diseases driven by Th1 and Th2 subsets suggests a common aetiology. A population-based study using computerized general practice data. Clin Exp Allergy 2002;32:37–42.
  23. Stene LC, Nafstad P: Relation between occurrence of type 1 diabetes and asthma. Lancet 2001;357:607–608.
  24. Illi S, von Mutius E, Lau S, Bergmann R, Niggemann B, Sommerfeld C, Wahn U: Early childhood infectious diseases and the development of asthma up to school age: A birth cohort study. BMJ 2001;322:390–395.
  25. Gibbon C, Smith T, Egger P, Betts P, Phillips D: Early infection and subsequent insulin dependent diabetes. Arch Dis Child 1997;384–385.
  26. Maier LM, Twells RC, Howson JM, Lam AC, Clayton DG, Smyth DJ, Savage D, Carson D, Patterson CC, Smink LJ, Walker NM, Burren OS, Nutland S, Rance H, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Cucca F, Todd JA: Testing the possible negative association of type I diabetes and attopic disease by analysis of the interleukin 4 receptor gene. Genes Immun 2003;4:469–475.
  27. Svanes C, Jarvis D, Chinn S, et al: Childhood environment and adult atopy: Results from the European Community Respiratory Health Survey. J Allergy Clin Immunol 1999;103:415–420.
  28. Romagnani S: Human TH1 and TH2 subsets: Regulation of differentiation and role in protection and immunopathology. Int Arch Allergy Immunol 1992;98:279–285.
  29. Lensmar C, Prieto J, Dahlen B, Eklund A, Grunewald J, Roquet A: Airway inflammation and altered alveolar macrophage phenotype pattern after repeated low-dose allergen exposure of atopic asthmatic subjects. Clin Exp Allergy 1999;29:1632–1640.
  30. Magnan A, Mely L, Camilla CA, Badier M, Bongrand P, Vervloet D: Assessment of the TH1/TH2 paradigm in whole blood in atopy and asthma: Increased IFN-gamma-producing CD8+ T cells in asthma. Am J Respir Crit Care Med 2000;161:1790–1796.
  31. Liu AH: Endotoxin exposure in allergy and asthma: Reconciling a paradox J Allergy Clin Immunol 2002;109:379–392.
  32. Umetsu DT, Akbari O, DeKruiff RH: Regulatory T cells control the development of allergic disease and asthma. J Allergy Clin Immunol 2003;112:480–487.
  33. Azar ST, Tamim H, Beyhum HN, Habbal MZ, Almawi WY: Type I insulin-dependent diabetes is a Th1- and Th2-mediated autoimmune disease. Clin Diagn Lab Immunol 1999;6:306–310.
  34. Araujo LM, Lefort J, Nahori MA, Diem S, Zhu R, Dy M, Leite-de-Moraes MC, Bach JF, Vargaftig BB, Herbelin A: Exacerbated Th2-mediated airway inflammation and hyperesponsiveness in autoimmune diabetes-prone NOD mice: A critical role for CD1d-dependent NKT cells. Eur J Immunol 2004;34:327–335.
  35. Vianna EO, Garcia-Leme J: Allergen-induced airway inflammation in rats. Role of insulin. Am J Resp Crit Care Med 1995;151:809–814.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 15, 2003
Accepted: April 28, 2004
Published online: August 05, 2004
Issue release date: August 2004

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA


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