Prevalence of Congenital Hypothyroidism in Isfahan, Iran: Results of a Survey on 20,000 NeonatesHashemipour M.a,b · Amini M.a,b · Iranpour R.b · Sadri G.H.c · Javaheri N.a · Haghighi S.a · Hovsepian S.a · Javadi A.A.d · Nematbakhsh M.e · Sattari G.a
aIsfahan Endocrine & Metabolism Research Center, bDepartment of Pediatrics, School of Medicine, cDepartment of Social Medicine, School of Medicine, dDepartment of Infectious Diseases, School of Medicine, and eDepartment of Physiology, School of Medicine, Isfahan University of Medical Sciences & Health Services, Isfahan, Iran
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Aims: To evaluate the prevalence of congenital hypothyroidism (CH) in a screening program performed for the first time in Isfahan, Iran. Methods: From May 2002 to December 2002, T4 and TSH serum concentrations of 20,000 3- to 7-day-old newborns, born in all 17 hospitals of the city, were measured by radioimmunoassay and immunoradiometric assay, respectively. The newborns with abnormal screening results (TSH >20 mIU/l, T4 <6.5 µg/dl and based on the weight) were re-examined. Results: Of 531 recalled subjects (recall rate 2.6%), 54 were confirmed to be hypothyroid, showing a prevalence of 1:370 for CH. Conclusion: Considering the high frequency of CH, the necessity of implementing a routine screening program in the healthcare system of Isfahan Province is emphasized.
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