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Research Article

Free Access

The Complete Genome Sequence of Bacillus licheniformis DSM13, an Organism with Great Industrial Potential

Veith B.a · Herzberg C.a · Steckel S.a · Feesche J.b · Maurer K.H.b · Ehrenreich P.a · Bäumer S.a · Henne A.a · Liesegang H.a · Merkl R.a · Ehrenreich A.a · Gottschalk G.a

Author affiliations

aGöttingen Genomics Laboratory and Competence Centre for Genome Research on Bacteria, Institute of Microbiology and Genetics, University of Göttingen, Göttingen, and bHenkel KGaA, VBT Enzymtechnologie, Düsseldorf, Germany

Corresponding Author

Armin Ehrenreich

Genomics Laboratory and Competence Centre for Genome Research on Bacteria

Institute of Microbiology and Genetics, University of Göttingen

Grisebachstrasse 8, DE–37077 Göttingen (Germany)

Tel. +49 551 393833, Fax +49 551 393793, E-Mail aehrenr@gwdg.de

Related Articles for ""

J Mol Microbiol Biotechnol 2004;7:204–211

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The genome of Bacillus licheniformis DSM13 consists of a single chromosome that has a size of 4,222,748 base pairs. The average G+C ratio is 46.2%. 4,286 open reading frames, 72 tRNA genes, 7 rRNA operons and 20 transposase genes were identified. The genome shows a marked co-linearity with Bacillus subtilis but contains defined inserted regions that can be identified at the sequence as well as at the functional level. B. licheniformis DSM13 has a well-conserved secretory system, no polyketide biosynthesis, but is able to form the lipopeptide lichenysin. From the further analysis of the genome sequence, we identified conserved regulatory DNA motives, the occurrence of the glyoxylate bypass and the presence of anaerobic ribonucleotide reductase explaining that B. licheniformis is able to grow on acetate and 2,3-butanediol as well as anaerobically on glucose. Many new genes of potential interest for biotechnological applications were found in B. licheniformis; candidates include proteases, pectate lyases, lipases and various polysaccharide degrading enzymes.

© 2004 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: May 05, 2004
Accepted: May 13, 2004
Published online: September 17, 2004
Issue release date: September 2004

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 5

ISSN: 1464-1801 (Print)
eISSN: 1660-2412 (Online)

For additional information: http://www.karger.com/MMB

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