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Review

Center Median-Parafascicular Complex and Pain Control

Review

from a Neurosurgical Perspective

Weigel R. · Weigel R. · Krauss J.K. · Krauss J.K.

Author affiliations

Department of Neurosurgery, University Hospital, Mannheim, Germany

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Stereotact Funct Neurosurg 2004;82:115–126

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: August 12, 2004
Issue release date: August 2004

Number of Print Pages: 12
Number of Figures: 3
Number of Tables: 0

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: https://www.karger.com/SFN

Abstract

The center median-parafascicular (CM-Pf) complex, which constitutes the major portion of the intralaminar thalamus in man, has long been known to be involved in the processing of pain under normal and pathological conditions. Yet, these ‘forgotten’ nuclei with their rich connectivity to other thalamic nuclei, the basal ganglia and cortical areas have received only relatively little attention over the past two decades. With regard to the recent reinterest in functional stereotactic neurosurgery as a treatment option for chronic refractory pain, the CM-Pf complex has been reconsidered as a target. This review provides a systematic overview on the current knowledge about the anatomy and connectivity of the CM-Pf complex, neurophysiological studies, and on concepts of its role in pain processing under various conditions. We also review the previous experience with ablative surgery and deep brain stimulation of the CM-Pf complex. Studies in men and experimental animals indicate that the CM-Pf complex is part of a medial pain system, which appears to be involved primarily in affective and motivational dimensions of pain. Single-unit recordings from the CM-Pf complex have shown that the activity of CM-Pf cells is modified by painful stimuli. Under pathological conditions, bursting firing patterns and altered discharge rates were found. Thalamotomies targeting at the CM-Pf complex yielded beneficial results for chronic pain, but interpretation of the results is limited. With bifocal deep brain stimulation, short-term effects of CM-Pf stimulation were superior to those of somatosensory thalamic stimulation in neuropathic pain. There is evidence, that the CM-Pf complex might also be involved in the mediation of the beneficial effects of somatosensory thalamic stimulation and periventricular grey stimulation.

© 2004 S. Karger AG, Basel


References

  1. Benabid AL, Koudsie A, Benazzouz A, Piallat B, Krack P, Limousin-Dowsey P, Lebas JF, Pollak P: Deep brain stimulation for Parkinson’s disease. Adv Neurol 2001;86:405–412.
  2. Lozano AM, Dostrovsky J, Chen R, Ashby P: Deep brain stimulation for Parkinson’s disease: Disrupting the disruption. Lancet Neurol 2002;1:225–231.
  3. Krauss JK, Jankovic J, Grossman RG: Surgery for Parkinson’s Disease and Movement Disorders. Philadelphia, Lippincott Williams and Wilkins, 2001.
  4. Young RF: Brain stimulation; in North RB, Levy RM (eds): Neurosurgical Management of Pain. New York, Springer, 1997, pp 283–301.
  5. Nandi D, Aziz T, Carter H, Stein J: Thalamic field potentials in chronic central pain treated by periventricular gray stimulation – A series of eight cases. Pain 2003;101:97–107.
  6. Krauss JK, Pohle T, Weigel R, Burgunder JM: Deep brain stimulation of the centre median-parafascicular complex in patients with movement disorders. J Neurol Neurosurg Psychiatry 2002;72:546–548.
  7. Hariz MI, Bergenheim AT: Thalamic stereotaxis for chronic pain: Ablative lesion or stimulation? Stereotact Funct Neurosurg 1995;64:47–55.
  8. Gybels J, Kupers R, Nuttin B: Therapeutic stereotactic procedures on the thalamus for pain. Acta Neurochir (Wien) 1993;124:19–22.
  9. Davis KD, Lozano AM, Tasker RR, Dostrovsky JO: Brain targets for pain control. Stereotact Funct Neurosurg 1998;71:173–179.
  10. Tasker RR: History of lesioning for pain. Stereotact Funct Neurosurg 2001;77:163–165.
  11. Laitinen LV: Mesencephalotomy and thalamotomy for chronic pain; in Lunsford LD (ed): Modern Stereotactic Neurosurgery. Boston, Martinus Nijhoff Publishing, 1988.
  12. Gorecki JP: Thalamotomy for cancer pain; in Gildenberg PL, Tasker RR (eds): Textbook of Stereotactic and Functional Neurosurgery. New York, McGraw-Hill, 1998.
  13. Bendok B, Levy RM: Brain stimulation for persistent pain management; in Gildenberg PL, Tasker RR (eds): Textbook of Stereotactic and Functional Neurosurgery. New York, McGraw-Hill, 1998, pp 1539–1546.
  14. Kumar K, Toth C, Nath RK: Deep brain stimulation for intractable pain: A 15-year experience. Neurosurgery 1997;40:736–746.
  15. Krauss JK, Pohle T, Weigel R, Kalbarczyk A: Somatosensory thalamic stimulation versus center median-parafascicular complex stimulation in 11 patients with neuropathic pain. Stereotact Funct Neurosurg 2001;77:194.
    External Resources
  16. Le Gros Clark WE: The structure and connections of the thalamus. Brain 1932;55:406–470.
  17. Jones EG: The Thalamus. New York, Plenum Press, 1985.
  18. Walker AE: The Primate Thalamus. Chicago, University Chicago Press, 1938.
  19. Hassler R: Anatomy of the thalamus; in Schaltenbrand G, Bailey P (eds): Introduction to Stereotaxis with an Atlas of the Human Brain. Stuttgart, Thieme, 1959, pp 230–290.
  20. Vogt C, Vogt O: Thalamusstudien. 1. Zur Einführung. 2. Homogenität und Grenzgestaltung der Grisea des Thalamus. 3. Das Griseum centrale centrum medianum Luys. J Psychol Neurol 1941;50:32–154.
  21. Hirai T, Jones EG: A new parcellation of the human thalamus on the basis of histochemical staining. Brain Res Brain Res Rev 1989;14:1–34.
  22. Weigel R, Krauss JK, Jones EG: Anatomie und Nomenklatur der Basalganglien und des Thalamus; in Krauss JK, Volkmann J (eds): Tiefe Hirnstimulation. Darmstadt, Steinkopff, in press.
  23. Vogt C: La myéloarchitecture du thalamus du cercopithèque. J Psychol Neurol 1909;12:285–324.
  24. Luys JB: Recherches sur la système nerveux cerébrospinal: sa structure, ses functions, et ses maladies. Paris, Baillière, 1865.
  25. van Buren JM, Borke RC: Variations and Connections of the Human Thalamus. Heidelberg, Springer, 1972.
  26. Jones EG: Morphology, nomenclature, and connections of the thalamus and basal ganglia; in Krauss JK, Jankovic J, Grossman RG (eds): Surgery for Parkinson’s Disease and Movement Disorders. Philadelphia, Lippincott Williams & Wilkins, 2001, pp 24–47.
  27. Grünthal E: Der Zellbau im Thalamus der Säuger und des Menschen. J Psychol Neurol 1934;46:41–112.
  28. Mehler WR: Further notes on the center median nucleus of Luys; in Purpura DP, Yahr MD (eds): The Thalamus. New York, Columbia University Press, 1966, pp 109–122.
  29. Niimi K, Katayama K, Kanaseki T, Morimoto K: Studies on the derivation of the centre médian nucleus of Luys. Tokushima J Exp Med 1960;7:261–268.
  30. Mehler WR, Feferman ME, Nauta WJH: Ascending axon degeneration following anterolateral cordotomy: An experimental study in the monkey. Brain 1960;83:718–750.
  31. Mehler WR: The anatomy of the so-called ‘pain tract’ in man: An analysis of the course and distribution of the ascending fibers of the fasciculus anterolateralis; in French JD, Porter RW (eds): Basic Research in Paraplegia. Springfield, Thomas Publishing, 1962, pp 26–55.
  32. Boivie J: An anatomical reinvestigation of the termination of the spinothalamic tract in the monkey. J Comp Neurol 1979;186:343–369.
  33. Royce GJ, Bromley S, Gracco C: Subcortical projections to the centromedian and parafascicular thalamic nuclei in the cat. J Comp Neurol 1991;306:129–155.
  34. Guilbaud G, Bernard JF, Besson JM: Brain areas involved in nociception and pain; in Wall PD, Melzack R (eds): Textbook of Pain. Edinburgh, Churchill Livingstone, 1994, pp 113–128.
  35. Nauta WJ, Mehler WR: Projections of the lentiform nucleus in the monkey. Brain Res 1966;1:3–42.
  36. Sidibe M, Bevan MD, Bolam JP, Smith Y: Efferent connections of the internal globus pallidus in the squirrel monkey. 1. Topography and synaptic organization of the pallidothalamic projection. J Comp Neurol 1997;382:323–347.
  37. Hamilton BL: Projections of the nuclei of the periaqueductal grey matter in the cat. J Comp Neurol 1973;152:45–58.
  38. Reynolds DV: Surgery in the rat during electrical analgesia induced by focal brain stimulation. Science 1969;164:444–445.
  39. Vertes RP, Martin GF: Autoradiographic analysis of ascending projections from the pontine and mesencephalic reticular formation and the median raphe nucleus in the rat. J Comp Neurol 1988;275:511–541.
  40. Pare D, Smith Y, Parent A, Steriade M: Projections of brainstem core cholinergic and non-cholinergic neurons of cat to intralaminar and reticular thalamic nuclei. Neuroscience 1988;25:69–86.
  41. Ishida Y: Intralaminar thalamic responses to somatic and fastigial stimulation: Cortical inhibition and its blockade by strychnine in cats. Neuropharmacology 1977;16:163–170.
  42. Shiroyama T, Kayahara T, Yasui Y, Nomura J, Nakano K: The vestibular nuclei of the rat project to the lateral part of the thalamic parafascicular nucleus (centromedian nucleus in primates). Brain Res 1995;704:130–134.
  43. Yamasaki DS, Krauthamer GM, Rhoades RW: Superior collicular projection to intralaminar thalamus in rat. Brain Res 1986;378:223–233.
  44. Benevento LA, Rezak M, Santos A: An autoradiographic study of the projections of the pretectum in the rhesus monkey (Macaca mulatta): Evidence for sensorimotor links to the thalamus and oculomotor nuclei. Brain Res 1977;127:197–218.
  45. McBride RL, Sutin J: Projections of the locus coeruleus and adjacent pontine tegmentum in the cat. J Comp Neurol 1976;165:265–284.
  46. Jones BE, Yang TZ: The efferent projections from the reticular formation and the locus coeruleus studied by anterograde and retrograde axonal transport in the rat. J Comp Neurol 1985;242:56–92.
  47. Le Gros Clark WE, Russell WR: Observations on the efferent connexions of the centre median nucleus. J Anat 1939;73:255–262.
  48. Royce GJ, Mourey RJ: Efferent connections of the centromedian and parafascicular thalamic nuclei: An autoradiographic investigation in the cat. J Comp Neurol 1985;235:277–300.
  49. Berendse HW, Groenewegen HJ: Restricted cortical termination fields of the midline and intralaminar thalamic nuclei in the rat. Neuroscience 1991;42:73–102.
  50. Thompson SM, Robertson RT: Organization of subcortical pathways for sensory projections to the limbic cortex. 1. Subcortical projections to the medial limbic cortex in the rat. J Comp Neurol 1987;265:175–188.
  51. Vogt BA, Rosene DL, Pandya DN: Thalamic and cortical afferents differentiate anterior from posterior cingulate cortex in the monkey. Science 1979;204:205–207.
  52. Vogt BA, Pandya DN, Rosene DL: Cingulate cortex of the rhesus monkey. 1. Cytoarchitecture and thalamic afferents. J Comp Neurol 1987;262:256–270.
  53. Vogt LJ, Vogt BA, Sikes RW: Limbic thalamus in rabbit: Architecture, projections to cingulate cortex and distribution of muscarinic acetylcholine, GABAA, and opioid receptors. J Comp Neurol 1992;319:205–217.
  54. Jones EG, Leavitt RY: Retrograde axonal transport and the demonstration of non-specific projections to the cerebral cortex and striatum from thalamic intralaminar nuclei in the rat, cat and monkey. J Comp Neurol 1974;154:349–377.
  55. Steriade M, Glenn LL: Neocortical and caudate projections of intralaminar thalamic neurons and their synaptic excitation from midbrain reticular core. J Neurophysiol 1982;48:352–371.
  56. Kunzle H: Projections from the primary somatosensory cortex to basal ganglia and thalamus in the monkey. Exp Brain Res 1977;30:481–492.
  57. Kunzle H, Akert K: Efferent connections of cortical, area 8 (frontal eye field) in Macaca fascicularis. A reinvestigation using the autoradiographic technique. J Comp Neurol 1977;173:147–164.
  58. Deschenes M, Bourassa J, Doan VD, Parent A: A single-cell study of the axonal projections arising from the posterior intralaminar thalamic nuclei in the rat. Eur J Neurosci 1996;8:329–343.
  59. Feger J, Bevan M, Crossman AR: The projections from the parafascicular thalamic nucleus to the subthalamic nucleus and the striatum arise from separate neuronal populations: A comparison with the corticostriatal and corticosubthalamic efferents in a retrograde fluorescent double-labelling study. Neuroscience 1994;60:125–132.
  60. Pearce JM: The subthalamic nucleus and Jules Bernard Luys (1828–97). J Neurol Neurosurg Psychiatry 2001;71:783.
  61. Dempsey EW, Morison RS: The production of rhythmically recurrent cortical potentials after localized thalamic stimulation. Am J Physiol 1942;135:293–300.
  62. Albe-Fessard D, Kruger L: Duality of unit discharges from cat centrum medianum in response to natural and electrical stimulation. J Neurophysiol 1962;25:3–20.
  63. Albe-Fessard D, Besson JM: Convergent thalamic and cortical projection- the non-specific system; in Iggo A (ed): Handbook of Sensory Physiology. Somatosensory System. Berlin, Springer, 1973, vol 2, pp 490–560.
  64. Dong WK, Ryu H, Wagman IH: Nociceptive responses of neurons in medial thalamus and their relationship to spinothalamic pathways. J Neurophysiol 1978;41:1592–1613.
  65. Grunwerg BS, Krauthamer GM: Sensory responses of intralaminar thalamic neurons activated by the superior colliculus. Exp Brain Res 1992;88:541–550.
  66. Bushnell MC, Duncan GH: Sensory and affective aspects of pain perception: Is medial thalamus restricted to emotional issues? Exp Brain Res 1989;78:415–418.
  67. Benabid AL, Henriksen SJ, McGinty JF, Bloom FE: Thalamic nucleus ventro-postero-lateralis inhibits nucleus parafascicularis response to noxious stimuli through a non-opioid pathway. Brain Res 1983;280:217–231.
  68. Gura EV, Garkavenko VV, Limansky Yu P: Influences of central gray matter stimulation on thalamic neuron responses to high- and low-threshold stimulation of trigeminal nerve structures. Neuroscience 1991;41:681–693.
  69. Ishijima B, Yoshimasu N, Fukushima T, Hori T, Sekino H, Sano K: Nociceptive neurons in the human thalamus. Confin Neurol 1975;37:99–106.
  70. Tsubokawa T, Moriyasu N: Follow-up results of centre-median thalamotomy for relief of intractable pain. Confin Neurol 1975;37:280–284.
  71. Hirato M, Kawashima Y, Shibazaki T, Shibasaki T, Ohye C: Pathophysiology of central (thalamic) pain: A possible role of the intralaminar nuclei in superficial pain. Acta Neurochir Suppl 1991;52:133–136.
  72. Rinaldi PC, Young RF, Albe-Fessard D, Chodakiewitz J: Spontaneous neuronal hyperactivity in the medial and intralaminar thalamic nuclei of patients with deafferentation pain. J Neurosurg 1991;74:415–421.
  73. Jeanmonod D, Magnin M, Morel A: Low-threshold calcium spike bursts in the human thalamus. Common physiopathology for sensory, motor and limbic positive symptoms. Brain 1996;119:363–375.
  74. Hécaen H, Talairach J, David M, Dell MB: Coagulations limitées du thalamus dans les algies du syndrome thalamique. Rev Neurol 1949;81:917–931.
  75. Sano K, Yoshioka M, Ogashiwa M, Ishijima B, Ohye C: Thalamolaminotomy. A new operation for relief of intractable pain. Confin Neurol 1966;27:63–66.
  76. Thoden U, Doerr M, Dieckmann G, Krainick JU: Medial thalamic permanent electrodes for pain control in man: an electrophysiological and clinical study. Electroencephalogr Clin Neurophysiol 1979;47:582–591.
  77. Ray CD, Burton CV: Deep brain stimulation for severe, chronic pain. Acta Neurochir Suppl 1980;30:289–293.
  78. Pert A, Yaksh T: Sites of morphine-induced analgesia in the primate brain: Relation to pain pathways. Brain Res 1974;80:135–140.
  79. Pert A, Yaksh T: Localization of the antinociceptive action of morphine in primate brain. Pharmacol Biochem Behav 1975;3:133–138.
  80. Pert CB, Kuhar MJ, Snyder SH: Autoradiograhic localization of the opiate receptor in rat brain. Life Sci 1975;16:1849–1853.
  81. Lim RKS, Krauthamer G, Guzman F, Fulp RR: Central nervous system activity associated with the pain evoked by bradykinin and its alternation by morphine and aspirin. Proc Natl Acad Sci USA 1969;63:705–712.
  82. Bullitt E: Induction of c-fos-like protein within the lumbar spinal cord and thalamus of the rat following peripheral stimulation. Brain Res 1989;493:391–397.
  83. Morgan JI, Curran T: Role of ion flux in the control of c-fos expression. Nature 1986;322:552–555.
  84. Kohnstamm O, Quensel F: Centrum receptorium der formation reticularis und gekreuzt aufsteigende Bahn. Dtsch Z Nervenheilk 1908;36:182.
  85. French JD, Verzeano M, Magoun HW: An extralemniscal sensory system in the brain. Arch Neurol 1953;69:505–518.
  86. Le Gros Clark WE: The termination of ascending tracts in the thalamus of the macaque monkey. J Anat Lond 1936;71:7–40.
  87. Willis WD, Trevino DL, Coulter JD, Maunz RA: Responses of primate spinothalamic tract neurons to natural stimulation of hindlimb. J Neurophysiol 1974;37:358–372.
  88. Albe-Fessard D, Condes-Lara M, Sanderson P: The focal tonic cortical control of intralaminar thalamic neurons may involve a cortico-thalamic loop. Acta Morphol Hung 1983;31:9–26.
  89. Albe-Fessard D, Cesaro P, Hamon B: Effect of striatal stimulation on cellular activities of medial thalamic neurons studied in rats. Exp Brain Res 1983;50:34–44.
  90. Dalsass M, Krauthamer GM: Intracellular responses in the centrum medianum-parafascicular complex of the cat following medial and lateral caudate, substantia nigra and peripheral stimulation. Neurosci Lett 1981;21:171–176.
  91. Olausson B, Shyu BC, Rydenhag B: Projection from the thalamic intralaminar nuclei on the isocortex of the rat: A surface potential study. Exp Brain Res 1989;75:543–554.
  92. Royce GJ: Cells of origin of subcortical afferents to the caudate nucleus: A horseradish peroxidase study in the cat. Brain Res 1978;153:465–475.
  93. Giesler GJ Jr, Yezierski RP, Gerhart KD, Willis WD: Spinothalamic tract neurons that project to medial and/or lateral thalamic nuclei: Evidence for a physiologically novel population of spinal cord neurons. J Neurophysiol 1981;46:1285–1308.
  94. Casey KL, Jones EG: Supraspinal mechanisms: An overview of ascending pathways: Brainstem and thalamus. Neurosci Res Prog Bull 1978;16:103–118.
  95. Peschanski M, Guilbaud G, Gautron M: Posterior intralaminar region in rat: Neuronal responses to noxious and nonnoxious cutaneous stimuli. Exp Neurol 1981;72:226–238.
  96. Rainville P, Duncan GH, Price DD, Carrier B, Bushnell MC: Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science 1997;277:968–971.
  97. Minamimoto T, Kimura M: Participation of the thalamic CM-Pf complex in attentional orienting. J Neurophysiol 2002;87:3090–3101.
  98. Matsumoto N, Minamimoto T, Graybiel AM, Kimura M: Neurons in the thalamic CM-Pf complex supply striatal neurons with information about behaviorally significant sensory events. J Neurophysiol 2001;85:960–976.
  99. Nyquist JK, Greenhoot JH: Responses evoked from the thalamic centrum medianum by painful input: Suppression by dorsal funiculus conditioning. Exp Neurol 1973;39:215–222.
  100. Llinas RR, Ribary U, Jeanmonod D, Kronberg E, Mitra PP: Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography. Proc Natl Acad Sci USA 1999;96:15222–15227.
  101. Lenz FA, Kwan HC, Dostrovsky JO, Tasker RR: Characteristics of the bursting pattern of action potentials that occurs in the thalamus of patients with central pain. Brain Res 1989;496:357–360.
  102. Dostrovsky JO: Role of thalamus in pain. Prog Brain Res 2000;129:245–257.
  103. Sherman SM, Guillery RW: Functional organization of thalamocortical relays. J Neurophysiol 1996;76:1367–1395.
  104. Chaplan SR, Pogrel JW, Yaksh TL: Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia. J Pharmacol Exp Ther 1994;269:1117–1123.
  105. Malmberg AB, Yaksh TL: Effect of continuous intrathecal infusion of omega-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats. Pain 1995;60:83–90.
  106. Bowersox SS, Gadbois T, Singh T, Pettus M, Wang YX, Luther RR: Selective N-type neuronal voltage-sensitive calcium channel blocker, SNX-111, produces spinal antinociception in rat models of acute, persistent and neuropathic pain. J Pharmacol Exp Ther 1996;279:1243–1249.
  107. Brose WG, Gutlove DP, Luther RR, Bowersox SS, McGuire D: Use of intrathecal SNX-111, a novel, N-type, voltage-sensitive, calcium channel blocker, in the management of intractable brachial plexus avulsion pain. Clin J Pain 1997;13:256–259.
  108. Price DD: Psychological and neural mechanisms of the affective dimension of pain. Science 2000;288:1769–1772.
  109. Spiegel EA, Wycis HT, Marks M: Stereotaxic apparatus for operations on the human brain. Science 1947;106:349–350.
  110. Tasker RR: Thalamotomy. Neurosurg Clin N Am 1990;1:841–864.
  111. Leksell L, Meyerson BA, Forster DM: Radiosurgical thalamotomy for intractable pain. Confin Neurol 1972;34:264.
  112. Richardson DE, Akil H: Pain reduction by electrical brain stimulation in man. 1. Acute administration in periaqueductal and periventricular sites. J Neurosurg 1977;47:178–183.
  113. Richardson DE, Akil H: Pain reduction by electrical brain stimulation in man. 2. Chronic self-administration in the periventricular gray matter. J Neurosurg 1977;47:184–194.
  114. Gybels J, Dom R, Cosyns P: Electrical stimulation of the central gray for pain relief in human: Autopsy data. Acta Neurochir Suppl 1980;30:259–268.
  115. Gybels J: Thalamic stimulation in neuropathic pain: 27 years later. Acta Neurol Belg 2001;101:65–71.
  116. Siegfried J: Intracerebral neurosurgery in the treatment of chronic pain. Schweiz Rundsch Med Prax 1998;87:314–317.
  117. Levy RM, Lamb S, Adams JE: Treatment of chronic pain by deep brain stimulation: Long-term follow-up and review of the literature. Neurosurgery 1987;21:885–893.
  118. Lenz FA, Dougherty PM: Pain processing in the human thalamus; in Steriade M, Jones EG, McCormick DA (eds): Thalamus Experimental and Clinical Aspects. Amsterdam, Elsevier Science, 1997, pp 617–652.
  119. Hosobuchi Y, Adams JE, Linchitz R: Pain relief by electrical stimulation of the central gray matter in humans and its reversal by naloxone. Science 1977;197:183–186.
  120. Young RF, Chambi VI: Pain relief by electrical stimulation of the periaqueductal and periventricular gray matter. Evidence for a non-opioid mechanism. J Neurosurg 1987;66:364–371.
  121. Akil H, Richardson DE, Hughes J, Barchas JD: Enkephalin-like material elevated in ventricular cerebrospinal fluid of pain patients after analgetic focal stimulation. Science 1978;201:463–465.
  122. Peschanski M, Besson JM: Diencephalic connections of the raphe nuclei of the rat brainstem: An anatomical study with reference to the somatosensory system. J Comp Neurol 1984;224:509–534.
  123. Andersen E, Dafny N: An ascending serotonergic pain modulation pathway from the dorsal raphe nucleus to the parafascicularis nucleus of the thalamus. Brain Res 1983;269:57–67.
  124. Yezierski RP, Wilcox TK, Willis WD: The effects of serotonin antagonists on the inhibition of primate spinothalamic tract cells produced by stimulation in nucleus raphe magnus or periaqueductal gray. J Pharmacol Exp Ther 1982;220:266–277.
  125. Mundinger F, Salomao JF: Deep brain stimulation in mesencephalic lemniscus medialis for chronic pain. Acta Neurochir Suppl 1980;30:245–258.
  126. Schaltenbrand G, Wahren W: Atlas for Stereotaxy of the Human Brain. Stuttgart, Thieme, 1977.
  127. Niizuma H, Kwak R, Ikeda S, Ohyama H, Suzuki J, Saso S: Follow-up results of centromedian thalamotomy for central pain. Appl Neurophysiol 1982;45:324–325.
  128. Sewards TV, Sewards MA: The medial pain system: Neural representations of the motivational aspect of pain. Brain Res Bull 2002;59:163–180.
  129. Scherder E, Bouma A, Slaets J, Ooms M, Ribbe M, Blok A, Sergeant J: Repeated pain assessment in Alzheimer’s disease. Dement Geriatr Cogn Disord 2001;12:400–407.
  130. Rub U, Del Tredici K, Del Turco D, Braak H: The intralaminar nuclei assigned to the medial pain system and other components of this system are early and progressively affected by the Alzheimer’s disease-related cytoskeletal pathology. J Chem Neuroanat 2002;23:279–290.
  131. Boivie J, Meyerson BA: A correlative anatomical and clinical study of pain suppression by deep brain stimulation. Pain 1982;13:113–126.
  132. Duncan GH, Kupers RC, Marchand S, Villemure JG, Gybels JM, Bushnell MC: Stimulation of human thalamus for pain relief: possible modulatory circuits revealed by positron emission tomography. J Neurophysiol 1998;80:3326–3330.
  133. Davis KD, Taub E, Duffner F, Lozano AM, Tasker RR, Houle S, Dostrovsky JO: Activation of the anterior cingulate cortex by thalamic stimulation in patients with chronic pain: A positron emission tomography study. J Neurosurg 2000;92:64–69.

Article / Publication Details

First-Page Preview
Abstract of Review

Published online: August 12, 2004
Issue release date: August 2004

Number of Print Pages: 12
Number of Figures: 3
Number of Tables: 0

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: https://www.karger.com/SFN


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