Skin Pharmacology and Physiology

Original Paper

Ectoin: An Effective Natural Substance to Prevent UVA-Induced Premature Photoaging

Buenger J. · Driller H.

Author affiliations

Merck KGaA, Pigments Cosmetics Actives, Business Unit Cosmetics, Research and Development, Darmstadt, Germany

Keywords: EctoinUVA radiationSecond messenger releaseTranscription factor AP-2Intercellular adhesion molecule-1Mitochondrial DNA mutation

Related Articles for ""
Skin Pharmacol Physiol 2004;17:232–237
https://doi.org/10.1159/000080216

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 18, 2004
Accepted: June 03, 2004
Published online: September 27, 2004
Issue release date: September – October

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: https://www.karger.com/SPP

Abstract

With the help of a new ‘UVA stress model’, it was shown that Ectoin protects the skin from the effects of UVA-induced cell damage in a number of different ways. Using cell cultures, high-performance thin-layer chromatography, gel electrophoresis mobility shift assays, reverse transcriptase polymerase chain reaction, ion exchange chromatography and UV spectroscopy, it was demonstrated that the UVA-induced second messenger release, transcription factor AP-2 activation, intercellular adhesion molecule-1 expression and mitochondrial DNA mutation could be prevented. The results obtained clearly demonstrate that Ectoin counteracts the effects of UVA-induced and accelerated skin aging at different cell levels.

© 2004 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 18, 2004
Accepted: June 03, 2004
Published online: September 27, 2004
Issue release date: September – October

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: https://www.karger.com/SPP

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2004, Vol.17, No. 5

September – October

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