Near Infrared Spectroscopy and Transcranial Doppler in Monohemispheric StrokeVernieri F.a · Rosato N.b,c · Pauri F.a,c · Tibuzzi F.b · Passarelli F.a · Rossini P.M.a,c
aAFaR-CRCCS, Centro di Ricovero e Cura a Carattere Scientifico, Divisione di Neurologia, Ospedale Fatebenefratelli, Roma, bDipartimento di Medicina Sperimentale e Scienze Biochimiche, Università ‘Tor Vergata’ Roma, and cIRCCS, Centro S. Giovanni di Dio – Fatebenefratelli, Brescia, Italia
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
We simultaneously performed near infrared spectroscopy (NIRS) and transcranial Doppler (TCD) to evaluate the effects of hypercapnia as well as of scalp ischemia on the blood flow at two different depth levels within the brain and of the scalp vessels. A decrease in the backscattered light intensity, meaning an increment of blood volume, was detected at the end of hypercapnia in all healthy subjects. This decrement was partly masked by ischemia in the cutaneous vessels. In 2 patients with a monohemispheric lesion in the middle cerebral artery (MCA) territory, an increase in NIRS response was found in the healthy hemisphere, while in the stroke side the CO2-induced changes were negligible. TCD data showed a similar increment of blood flow velocity to the hypercapnia in both hemispheres, with no differences between the affected and normal side in 1 patient, whereas in the second one, no increment was observed on the affected side, probably due to internal carotid artery stenosis. The two methods nicely integrate: TCD mainly tests subcortical changes in the MCA flow, while NIRS is exquisitely sensitive to cortical arterioles and capillary blood flow modifications.
Chance B: Optical methods. Annu Rev Biophys Chem 1991;20:1–28.
- Delpy DT, Cope M, Van der Zee P, Arridge S, Vray S, Wyatt JS: Estimation of optical pathlength through tissue from direct time of flight measurements. Phys Med Biol 1988;33:1433–1442.
- Reynolds EOR, Wyatt JS, Azzopardi D, Delpy DT, Cady EB, Cope M, Wray S: New non-invasive methods for assessing brain oxygenation and haemodynamics. Br Med Bull 1988;44:1052–1075.
- Elwell CE, Cope M, Edwards AD, Wyatt JS, Delpy DT, Reynolds EO: Quantification of adult cerebral hemodynamics by near infrared spectroscopy. J Appl Physiol 1994;77:2753–2760.
- McCormick PW, Stewart M, Goetting MG, Dujovny M, Lewis G, Ausman JI: Noninvasive cerebral optical spectroscopy for monitoring cerebral oxygen delivery and hemodynamics. Crit Care Med 1991;19:89–97.
- McCormick PW, Stewart M, Lewis G, Dujovny M, Ausman JI: Intracerebral penetration of infrared light. J Neurosurg 1992;76:315–318.
- Smielewski P, Czosnyka M, Pickard JD, Kirkpatrick P: Clinical evaluation of near-infrared spectroscopy for testing cerebrovascular reactivity in patients with carotid artery disease. Stroke 1997;28:331–338.
- Smielewski P, Kirkpatrick P, Minhas P, Pickard JD, Czosnyka M: Can cerebrovascular reactivity be measured with Near-Infrared spectroscopy? Stroke 1995;26:2285–2292.
Fantini S, Franceschini MA, Maier JS, Walker SA, Barbieri B, Gratton E: Frequency-domain multichannel optical detector for non-invasive tissue spectroscopy and oximetry. Opt Eng 1995;34:32–42.
- Widder B, Kleiser B, Krapf H: Course of cerebrovascular reactivity in patients with carotid artery occlusion. Stroke 1994;25:1963–1967.
- Coyle P, Panzenbeck MJ: Collateral development of carotid artery occlusion in Fischer 344 rats. Stroke 1990;21:316–321.
- Aaslid R, Lindegaard KF, Sorteberg W, Nornes H: Cerebral autoregulation dynamics in humans. Stroke 1989;20:45–52.
- Aaslid R, Markwalder TM, Nornes H: Non-invasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 1982;57:769–774.
- Bishop CCR, Powell S, Rutt D, Browse NL: Transcranial Doppler measurement of middle cerebral artery blood flow velocity: A validation study. Stroke 1986;17:913–915.
- Ringelstein EB, Van Eyck S, Mertens I: Evaluation of cerebral vasomotor reactivity by various vasodilating stimuli: Comparison of CO2 to acetazolamide. J Cereb Blood Flow Metab 1992;12:162–168.
- Ringelstein EB, Sievers C, Ecker S, Schneider PA, Otis SM: Noninvasive assessment of CO2-induced cerebral vasomotor response in normal individuals and patients with internal carotid artery occlusion. Stroke 1988;19:963–969.
- Germon TJ, Young AE, Manara AR, Nelson RJ: Near infrared spectroscopy in adults: Effects of extracranial ischaemia and intracranial hypoxia on estimation of cerebral oxygenation. J Neurol Neurosurg Psychiatry 1995;58:477–479.
Sakatani K, Xie Y, Lichty W, Li S, Zuo H: Language-activated cerebral blood oxygenation and hemodynamic changes of the left prefrontal cortex in poststroke aphasic patients. A near infrared spectroscopy study. Stroke 1998;229:1299–1304.
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.