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Clinical and Laboratory Investigations

Kenogen in Female Androgenetic Alopecia

A Longitudinal Study

Guarrera M. · Rebora A.

Author affiliations

Department of Endocrinological and Metabolic Sciences, Section of Dermatology, University of Genoa, Genoa, Italy

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Dermatology 2005;210:18–20

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigations

Received: May 21, 2004
Accepted: August 05, 2004
Published online: January 28, 2005
Issue release date: December 2004

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

Background: Kenogen indicates the physiological interval of the hair cycle in which the hair follicle remains empty after the telogen hair has been extruded and before a new anagen hair emerges. Kenogen frequency and duration are greater in men and women with androgenetic alopecia (AGA). Objective: To study the relationship of kenogen with female AGA. Methods: A woman with AGA, studied 14 years before, was re-examined for 2 years by the phototrichogram technique. Kenogen was identified when telogen lasted 3 months and shedding left the follicle empty. Results: Kenogen lasted 1–5 months, the longest duration affecting cycles of vellus hairs, and involved more hair follicles (16 vs. 8%) than in the first observation. Cycles of vellus hairs increased in number from 4 to 13%, and cycles with a normal succession of phases decreased from 60 to 32%. Conclusions: The number of kenogen phases increased in parallel with vellus hairs and the diminished number of normal hair cycles, features that mark AGA aggravation. Kenogen seems to be related also to the progression of female AGA.

© 2005 S. Karger AG, Basel


References

  1. Rebora A, Guarrera M: Kenogen: A new phase of the hair cycle? Dermatology 2002;205:108–110.
  2. Rebora A, Guarrera M: Teloptosis and kenogen: Two new concepts in trichology. Arch Dermatol 2004;140:619–620.
  3. Piérard-Franchimont C, Piérard GE: Teloptosis, a turning point in hair shedding biorhythms. Dermatology 2001;203:115–117.
  4. Paus R: Principles of hair cycle control. J Dermatol 1998;25:793–802.
  5. Guarrera M, Rebora A: Anagen hairs may fail to replace telogen hairs in early androgenetic female alopecia. Dermatology 1996;192:28–31.
  6. Guarrera M, Ciulla MP: A quantitative evaluation of hair loss: The phototrichogram. J Appl Cosmetol 1986;4:61–66.
  7. Van Neste DJ, de Brouwer B, de Coster W: The phototrichogram: Analysis of some technical factors of variation. Skin Pharmacol 1994;7:67–72.
  8. Whiting DA: Possible mechanisms of miniaturization during androgenetic alopecia or pattern hair loss. J Am Acad Dermatol 2001;45(suppl 3):S81–S86.
    External Resources
  9. Courtois M, Loussouarn G, Hourseau C, Grollier JF: Hair cycle and alopecia. Skin Pharmacol 1994;7:84–89.
  10. Birch MP, Lalla SC, Messenger AG: Female pattern hair loss. Clin Exp Dermatol 2002;27:383–388.

Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigations

Received: May 21, 2004
Accepted: August 05, 2004
Published online: January 28, 2005
Issue release date: December 2004

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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