The Ecarin Clotting Time, a Universal Method to Quantify Direct Thrombin InhibitorsNowak G.
Research Group ‘Pharmacological Haemostaseology’, Medical Faculty, Friedrich Schiller University Jena, Jena, Germany
Prof. Dr. Götz Nowak
Friedrich Schiller University Jena, Medical Faculty
Research Group ‘Pharmacological Haemostaseology’
Drackendorfer Strasse 1, DE–07747 Jena (Germany)
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The ecarin clotting time (ECT) is a meizothrombin generation test that allows for precise quantification of direct thrombin inhibitors. The ECT has demonstrated its usefulness for more than 10 years in biochemical-pharmacological investigations as well as in clinical research and in the clinical routine. It has proved valuable especially as a drug-monitoring method in r-hirudin therapy. This test has been adjusted to clinical requirements by numerous modifications. Following the description of the biochemical background and the measuring principle of the ECT, this article gives a short survey of several modifications of the ECT for both preclinical and clinical use, e.g., for biochemical investigations, as a point-of-care method and for cardiac surgery. Advantages and disadvantages of these methods are discussed.
© 2004 S. Karger AG, Basel
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