Ophthalmologica
Case Report
Intraocular Levels of Methotrexate after Oral Low-Dose Treatment in Chronic UveitisPuchta J.a · Hattenbach L.-O.a · Baatz H.baDepartment of Ophthalmology, Johann Wolfgang Goethe University, Frankfurt/Main, and bEye Center, Recklinghausen, Germany
Keywords: Methotrexate, intraocularUveitis |
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Article / Publication Details
Received: January 30, 2004
Accepted: June 11, 2004
Published online: January 06, 2005
Issue release date: January – February
Number of Print Pages: 2
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)
For additional information: https://www.karger.com/OPH
Abstract
Purpose: To determine the intraocular levels of methotrexate in low-dose treatment of noninfectious uveitis. Methods: One day after oral administration, the methotrexate level was measured in the aqueous humor and serum of a patient with noninfectious uveitis, who underwent cataract surgery. A fluorescence polarization immunoassay was used for determination. Results: After oral administration, methotrexate was only measurable in aqueous humor but not in serum. Conclusion: In uveitis, orally administered low-dose methotrexate reaches detectable levels in aqueous humor, even in the absence of detectable levels in serum.
© 2005 S. Karger AG, Basel
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Article / Publication Details
Received: January 30, 2004
Accepted: June 11, 2004
Published online: January 06, 2005
Issue release date: January – February
Number of Print Pages: 2
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)
For additional information: https://www.karger.com/OPH
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