Nephron Experimental Nephrology
Original Paper
Sulfated Hyaluronic Acid, a Potential Selectin Inhibitor, Ameliorates Experimentally Induced Crescentic GlomerulonephritisOgawa D.a · Shikata K.a · Matsuda M.a · Akima K.b · Iwahashi M.a · Okada S.a · Tsuchiyama Y.a · Shikata Y.a · Wada J.a · Makino H.aaDepartment of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, and bDepartment of Pharmaceutics, Research Center, Shiseido Corporation, Tokyo, Japan
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Article / Publication Details
Received: January 05, 2004
Accepted: June 11, 2004
Published online: January 14, 2005
Issue release date: January 2005
Number of Print Pages: 1
Number of Figures: 4
Number of Tables: 2
eISSN: 1660-2129 (Online)
For additional information: https://www.karger.com/NEE
Abstract
Background/Aims: Sulfated polysaccharides are known to interfere with the binding of selectins and their ligands. Recently, we demonstrated that sulfated hyaluronic acid (SHA), a synthetic sulfated polysaccharide, showed preventive and therapeutic effects on experimental mesangial proliferative glomerulonephritis. Here we evaluated the protective potential of SHA on crescentic glomerulonephritis, using nephrotoxic serum (NTS) nephritis in Wistar-Kyoto (WKY) rats. Methods: Crescentic glomerulonephritis was induced by injection of NTS in WKY rats. Rats subsequently received intraperitoneal administration of SHA (0.5 or 1.5 mg/kg/day) or non-sulfated hyaluronic acid (HA) (1.5 mg/kg/day) for 14 days. The urinary protein excretion was measured, and expression of selectins, intraglomerular leukocytes and crescent formation were examined by immunohistochemistry. In addition, we examined the urinary protein excretion of SHA (1.5 mg/kg/day) administered from day 7 after the induction of crescentic glomerulonephritis. Results: The expression of P-selectin was increased in the glomerulus of crescentic glomerulonephritis. SHA reduced proteinuria, macrophage infiltration, and crescent formation in a dose-dependent manner. Furthermore, administration of SHA (1.5 mg/kg/day) from day 7 also reduced the urinary protein excretion on day 14 compared with that in saline and HA group. Conclusion: Our results suggest that SHA inhibits intraglomerular infiltration of macrophages, and prevents progression of experimental crescentic glomerulonephritis. Sulfated polysaccharides might be beneficial for the treatment of crescentic glomerulonephritis.
© 2005 S. Karger AG, Basel
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Article / Publication Details
Received: January 05, 2004
Accepted: June 11, 2004
Published online: January 14, 2005
Issue release date: January 2005
Number of Print Pages: 1
Number of Figures: 4
Number of Tables: 2
eISSN: 1660-2129 (Online)
For additional information: https://www.karger.com/NEE
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