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Special Article

Mannheim Intima-Media Thickness Consensus

on Behalf of the Advisory Board of the 3rd Watching the Risk Symposium 2004,13th European Stroke Conference, Mannheim, Germany, May 14, 2004

Touboul P.-J. · Hennerici M.G. · Meairs S. · Adams H. · Amarenco P. · Desvarieux M. · Ebrahim S. · Fatar M. · Hernandez Hernandez R. · Kownator S. · Prati P. · Rundek T. · Taylor A. · Bornstein N. · Csiba L. · Vicaut E. · Woo K.S. · Zannad F.

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Cerebrovasc Dis 2004;18:346–349

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Article / Publication Details

First-Page Preview
Abstract of Special Article

Published online: December 09, 2004
Issue release date: December 2004

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: https://www.karger.com/CED

Abstract

Intima-media thickness (IMT) is increasingly used in clinical trials as a surrogate end point for determining the success of interventions that lower risk factors for atherosclerosis. The necessity for unified criteria to distinguish early atherosclerotic plaque formation from thickening of IMT and to standardize IMT measurements is addressed in this consensus statement. Plaque is defined as a focal structure that encroaches into the arterial lumen of at least 0.5 mm or 50% of the surrounding IMT value or demonstrates a thickness of ≧1.5 mm as measured from the media-adventitia interface to the intima-lumen interface. Standard use of IMT measurements is recommended in all epidemiological and interventional trials dealing with vascular diseases to improve characterization of the population investigated. The consensus concludes that there is no need to ‘treat IMT values’ nor to monitor IMT values in individual patients apart from few exceptions. Although IMT has been suggested to represent an important risk marker, it does not fulfill the characteristics of an accepted risk factor. Standardized methods recommended in this consensus statement will foster homogenous data collection and analysis. This will help to improve the power of studies incorporating IMT measurements and to facilitate the merging of large databases for meta-analyses.

© 2004 S. Karger AG, Basel


References

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Article / Publication Details

First-Page Preview
Abstract of Special Article

Published online: December 09, 2004
Issue release date: December 2004

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: https://www.karger.com/CED


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