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Original Research Article

Autonomic Function Assessed by Heart Rate Variability Is Normal in Alzheimer’s Disease and Vascular Dementia

Allan L.M.a · Kerr S.R.J.a · Ballard C.G.c · Allen J.b · Murray A.b · McLaren A.T.a · Kenny R.A.a

Author affiliations

aInstitute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, and bRegional Medical Physics Department, Freeman Hospital, Newcastle upon Tyne, and cWolfson Centre for Age-Related Disorders, King’s College London, London, UK

Related Articles for ""

Dement Geriatr Cogn Disord 2005;19:140–144

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: June 18, 2004
Published online: February 11, 2005
Issue release date: February 2005

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

Heart rate variability (HRV) is a sensitive method for the assessment of autonomic function and requires little cooperation from the subject, making it suitable for use in dementia. Preliminary studies have suggested that HRV may be impaired in Alzheimer’s disease (AD). HRV has not been studied in vascular dementia (VAD). We investigate autonomic function in AD and VAD, using power spectral analysis of HRV. One hundred and fourteen participants were evaluated (14 AD, 20 VAD and 80 controls). The resting ECG was recorded for 5 min with participants in the supine position. Power spectral analysis used to obtain spectral bands in the very-low-frequency (<0.04 Hz), low-frequency (0.04–0.15 Hz) and high-frequency (0.15–0.40 Hz) bands and total spectral power (<0.40 Hz) according to international HRV guidelines. There were no differences in HRV in patients with AD or VAD when compared with controls.

© 2005 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: June 18, 2004
Published online: February 11, 2005
Issue release date: February 2005

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM


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