Dementia and Geriatric Cognitive Disorders

Original Research Article

Dementia in First-Degree Relatives of Patients with Frontotemporal Dementia

A Family History Study

Gräsbeck A.a,b · Horstmann V.c · Nilsson K.a · Sjöbeck M.d · Sjöström H.a · Gustafson L.a

Author affiliations

aDepartment of Psychogeriatrics, bSwedish National Institute of Health Care and Sciences, cUnit of Gerontology and Care for the Elderly and dDepartment of Pathology, Lund University, Lund, Sweden

Keywords: Frontotemporal dementiaOrganic dementiaFamily history studyIncidenceFirst-degree relativesFamilial aggregation

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Dement Geriatr Cogn Disord 2005;19:145–153
https://doi.org/10.1159/000082886

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: June 18, 2004
Published online: February 11, 2005
Issue release date: February 2005

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

Several studies have found a clustering of dementia in relatives of patients with frontotemporal dementia (FTD). This study analysed the familial aggregation of FTD specifically as well as the occurrence of dementia in general in first-degree relatives of patients with FTD. A family history study was carried out on 478 first-degree relatives of 74 index patients suffering from FTD. Cases of organic dementia and of FTD were diagnosed according to internationally accepted diagnostic criteria. Age- and sex-specific incidences of organic dementia and of FTD were calculated as was the proportion of FTD in relation to organic dementia in general; comparisons with clinical and population studies were made. There was a tenfold increase in the incidence of FTD in the first-degree relatives of FTD patients compared with the incidence of FTD in a population study. The proportion of FTD in relation to all types of organic dementia was much higher in relatives of FTD patients compared to the corresponding proportions in clinical and population-based studies. There was a small, non-significant difference between the present family history study and the population studies as regards the incidence of organic dementia. The findings suggest that hereditary and/or shared environmental factors are strongly involved in the aetiology of FTD. There were no indications of familial clustering of organic dementia in general in relatives of FTD patients.

© 2005 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: June 18, 2004
Published online: February 11, 2005
Issue release date: February 2005

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

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2005, Vol.19, No. 2-3

February 2005

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