Dermatology
Case Report
Mucosal Pigmentation after Oral Lichen planus Treatment with Topical TacrolimusFricain J.C.a · Sibaud V.c · Campana F.a · Lepreux S.b · Taïeb A.caUFR Odontologie et bService d’Anatomopathologie, Hôpital Pellegrin, et cService de Dermatologie, Hôpital Saint-André, Bordeaux, France
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Article / Publication Details
Received: May 06, 2004
Accepted: September 17, 2004
Published online: April 11, 2005
Issue release date: March 2005
Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0
ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)
For additional information: https://www.karger.com/DRM
Abstract
Erosive oral lichen planus (OLP) is a painful chronic inflammatory disease that is sometimes resistant to systemic or topical therapies. Topical steroids remain the mainstay of therapy, but topical tacrolimus has recently been used to treat OLP resistant to topical corticosteroids. Topical tacrolimus appears as an effective and safe treatment of symptomatic OLP. We report the first histopathologically documented case of oral mucosa pigmentation after OLP treatment with topical tacrolimus. The relation between tacrolimus treatment and staining was suggested by the appearance of pigmentation during topical tacrolimus treatment and its clinical disappearance when treatment was stopped. Histopathology showed an increase in melanocyte numbers and melanogenesis.
© 2005 S. Karger AG, Basel
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External Resources
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Article / Publication Details
Received: May 06, 2004
Accepted: September 17, 2004
Published online: April 11, 2005
Issue release date: March 2005
Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0
ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)
For additional information: https://www.karger.com/DRM
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