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Original Paper

A New Ossicle Homograft Inactivation/Preservation Procedure: Clinical Results

Romualdez J.A.a · Stauffer E.b · Häusler R.a · Hotz M.A.a

Author affiliations

Departments of aENT, Head and Neck Surgery and bPathology, Inselspital, University of Berne, Berne, Switzerland

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ORL 2005;67:34–38

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 14, 2004
Accepted: November 11, 2004
Published online: March 07, 2005
Issue release date: April 2005

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: https://www.karger.com/ORL

Abstract

A new NaOH-autoclaving inactivation/preservation procedure (IPP) for ossicle homografts, complying with the actual infectious disease guidelines, has been developed and used in our institution for 5 years. This study compares the clinical and audiological results of middle ear reconstruction using the new NaOH-autoclaving inactivated ossicle homografts (22 patients) and the previously used cialit-formaldehyde inactivation procedure (28 patients). During the follow-up period, no homograft extrusion, resorption or disease transmission was observed either for the NaOH-autoclaving or for the cialit-formaldehyde protocol. A postoperative air-bone gap of less than 20 dB in 44% and a postoperative hearing improvement of 10–50 dB in 70% of patients complies with the published success rates of homograft ossiculoplasty in the literature. The analysis and comparison of both tested IPP-patient groups showed no statistically significant differences in the clinical and the audiological results. The NaOH-autoclaving inactivation/preservation protocol should increase ossicle homograft safety even with respect to prion exposure. The good anatomic and audiological long-term results of the new IPP protocol confirm homograft ossicles as a valid and inexpensive approach for middle ear reconstruction.

© 2005 S. Karger AG, Basel


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    External Resources
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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 14, 2004
Accepted: November 11, 2004
Published online: March 07, 2005
Issue release date: April 2005

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: https://www.karger.com/ORL


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