Hormone Research in Paediatrics

Original Paper

Adult Height in Patients Treated for Isolated Growth Hormone Deficiency: Role of Birth Weight

Di Cesare Merlone A.a · Bozzola E.a · Castelnovi C.a · Chiabotto P.b · Costante L.b · De Sanctis L.b · Tinelli C.c · Bozzola M.a

Author affiliations

aDepartment of Pediatrics, University of Pavia, Pavia; bPediatric Endocrinology, Regina Margherita Hospital, Torino and cBiometrics Unit, IRCCS San Matteo, Pavia, Italy

Keywords: Growth hormone deficiencyAppropriate for gestational ageSmall for gestational ageAdult height

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Horm Res 2005;63:102–106
https://doi.org/10.1159/000084414

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 08, 2004
Accepted: January 24, 2005
Published online: April 06, 2005
Issue release date: April 2005

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 1

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP

Abstract

To evaluate the effect of growth hormone (GH) administration on adult height (AH) in two groups of isolated GH-deficient (IGHD) children born either small (birth weight below –2 SD) or appropriate (birth weight above –2 SD) for gestational age (GA). Out of 35 prepubertal IGHD children, 14 small for GA (SGA, group A) and 21 appropriate for GA (AGA, group B) were examined. All patients received continuous GH treatment at a median dose of 0.028 mg/kg/day (range 0.023–0.032) in group A and 0.024 (range 0.023–0.028) in group B. GH treatment was administered for a period of 67.0 months (range 42.37–96.05) in group A and 54.31 months (range 47.14–69.31) in group B. All children were measured using a Harpenden stadiometer every 6 months until they reached AH (growth velocity <1 cm/year). The patients underwent a retesting a few months after stopping GH therapy. A significant difference was found between group A and B as expected for birth weight SD, –2.70 (range –2.87 to –2.29) and –0.73 (range –1.30 to 0.14) respectively (p < 0.000001) and interestingly also for body mass index SDS (BMI SDS) at retesting, 0.08 (range 0.30 to –1.51) and 0.61 (range 0.73 to –1.10) respectively (p < 0.04). We observed no significant differences between groups A and B in height (expressed as the SDS for chronological age, height SDS) at diagnosis (p = 0.75), height SDS at start of puberty (p = 0.51), height SDS at retesting (p = 0.50), target height SDS (TH SDS) (p = 0.47), AH SDS (p = 0.92), corrected height SDS (height SDS – TH SDS) (p = 0.60), BMI SDS at diagnosis (p = 0.25), GH dosage (p = 0.34) and therapy duration (p = 0.52). GH treatment with a standard dose in short IGHD children leads to a normalization of AH without any significant difference between SGA and AGA patients.

© 2005 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 08, 2004
Accepted: January 24, 2005
Published online: April 06, 2005
Issue release date: April 2005

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 1

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP

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2005, Vol.63, No. 2

April 2005

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