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Original Paper

Prevalence of Respiratory Symptoms and Diseases Associated with Gastroesophageal Reflux Disease

Róka R.a · Rosztóczy A.a · Izbéki F.a · Taybani Z.b · Kiss I.c · Lonovics J.a · Wittmann T.a

Author affiliations

aFirst Department of Medicine and bDepartment of Radiology, University of Szeged, Szeged, and cSecond Department of Internal Medicine, ‘Réthy Pál’ Hospital, Békéscsaba, Hungary

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Digestion 2005;71:92–96

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 04, 2004
Accepted: December 07, 2004
Published online: April 20, 2005
Issue release date: April 2005

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 3

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG

Abstract

Aim: Investigation of the prevalence of respiratory symptoms and diseases associated with gastroesophageal reflux disease (GERD). Patients and Methods: 299 subjects with GERD were submitted to upper gastrointestinal endoscopy and 24-hour esophageal pH monitoring and a symptom analysis. Results: Chronic respiratory symptoms or diseases were present in 18% (56/299). Chronic cough was observed in 42/56 patients, while typical reflux symptoms such as heartburn and acid regurgitation were observed in 30/56 and 24/56 cases, respectively. The prevalence of airway diseases was chronic bronchitis 12/56, asthma 10/56, recurrent pneumonia 10/56, chronic sinusitis 7/56 and chronic laryngitis 1/56. In patients with respiratory complications pathologic acid reflux was established in 29/51 cases on the basis of the DeMeester score, while 17/51 had pathologic postprandial, nocturnal or diurnal reflux events. Upper gastrointestinal endoscopy revealed a normal esophageal mucosa in 6/56, Savary-Miller stage I esophagitis in 23/56, stage II in 15/56, stage III in 5/56 and stage IV in 6/56 patients. Conclusions: These investigations have demonstrated an abnormal 24-hour pH score in about half of the patients with GERD-associated respiratory complications, and indicated that short reflux events are characteristic of the reflux activity in one third of this population.

© 2005 S. Karger AG, Basel


References

  1. Deschner WK, Benjamin SB: Extraesophageal manifestations of gastroesophageal reflux disease. Am J Gastroenterol 1989;84:1–5.
  2. Hogan WJ: Spectrum of supraesophageal complications of gastroesophageal reflux disease. Am J Med 1997;103:77S–83S.
    External Resources
  3. Tobin RW, Pope CE 2nd, Pellegrini CA, Emond MJ, Sillery J, Raghu G: Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1998;158:1804–1808.
  4. Gastal OL, Castell JA, Castell DO: Frequency and site of gastroesophageal reflux in patients with chest symptoms. Chest 1994;106:1793–1796.
  5. Harding SM, Guzzo MR, Richter JE: 24-h esophageal pH testing in asthmatics. Chest 1999;115: 654–659.
  6. Palombini BC, Villanova CA, Araujo E, Gastal OL, Alt DC, Stolz DP, Palombini CO: A pathogenic triad in chronic cough. Chest 1999;116:279–284.
  7. Schnatz PF, Castell JA, Castell DO: Pulmonary symptoms associated with gastroesophageal reflux: Use of ambulatory pH monitoring to diagnose and to direct therapy. Am J Gastroenterol 1996;91:1715–1719.
  8. Sontag SJ, O’Connell S, Khandelwal S, Miller T, Nemchausky B, Schnell TG, Serlovsky R: Most asthmatics have gastroesophageal reflux with or without bronchodilator therapy. Gastroenterology 1990;99:613–620.
  9. El-Serag HB, Sonnenberg A: Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology 1997;113:755–760.
  10. Gislason T, Janson C, Vermeire P, Plaschke P, Bjornsson E, Gislason D, Boman G: Respiratory symptoms and nocturnal gastroesophageal reflux: A population-based study of young adults in three European countries. Chest 2002;121:158–163.
  11. Harding SM: Gastroesophageal reflux, asthma, and mechanisms of interaction. Am J Med 2001;111:8S–12S.
    External Resources
  12. Ward BW, Wu WC, Richter JE, Hackshaw BT, Castell DO: Long-term follow-up of symptomatic status of patients with noncardiac chest pain: Is diagnosis of esophageal etiology helpful? Am J Gastroenterol 1987;82:215–218.
  13. Savary M, Miller G: L’oesophage. Manuel et atlas d’endoscopie. Solothurn, Gassamann, 1977.
  14. DeMeester TR, Johnson LF, Joseph GJ: Patterns of gastroesophageal reflux in health and disease. Am Surg 1976;184:459–469.
  15. Mason RJ, Öberg S, Cedric G, Bremner CG, Peters JH, Gadenstätter M, Ritter M, DeMeester TR: Postprandial gastroesophageal reflux in normal volunteers and symptomatic patients. J Gastrointest Surg 1998;2:342–349.
  16. Dalton CB: The esophageal motility laboratory. Materials and equipment; in Castell DO (ed): Esophageal Motility Testing. New York, Elsevier, 1987, pp 28–78.
  17. Rosztoczy A, Kovacs L, Wittmann T, Lonovics J, Pokorny G: Manometric assessment of impaired esophageal motor function in primary Sjögren’s syndrome. Clin Exp Rheumatol 2001;19:147–152.
  18. Richter JE, Blackwell JN, Wu WC: Esophageal manometry in 95 healthy adult volunteers. Dig Dis Sci 1987;32:583–592.
  19. Kahrilas PJ: Esophageal motor activity and acid clearance. Gastroenterol Clin North Am 1990;19:537–550.
  20. Kiss I, Rosztóczy A, Wittmann T, et al: New radiologic method for evaluation of motility disorders in gastroesophageal reflux disease (GERD). Z Gastroenterol 1994;32:A77.
  21. Sontag SJ, Schnell TG, Miller TQ, Khandelwal S, O’Connell S, Chejfec G, Greenlee H, Seidel UJ, Brand L: Prevalence of oesophagitis in asthmatics. Gut 1992;33:872–876.
  22. Field SK, Underwood M, Brant R, Cowie RL: Prevalence of gastroesophageal reflux symptoms in asthma. Chest 1996;109:316–322.
  23. Groen JN, Smout AJPM: Suproesophageal manifestations of gastro-oesophageal reflux disease. Eur J Gastroenterol Hepatol 2003;15:1339–1350.
  24. Jaspersen D, Kulig M, Labenz J, Leodolter A, Lind T, Meyer-Sabellek W, Vieth M, Willich SN, Lindner D, Stolte M, Malfertheiner P: Prevalence of extra-oesophageal manifestations in gastro-oesophageal reflux disease: An analysis based on the ProGERD Study. Aliment Pharmacol Ther 2003;17:1515–1520.
  25. Richter JE: Extraesophageal presentations of gastroesophageal reflux disease: An overview. Am J Gastroenterol 2000;95:S1–S3.
    External Resources
  26. Irwin RS, French CL, Curley FJ, Zawacki JK, Bennett FM: Chronic cough due to gastroesophageal reflux. Clinical, diagnostic, and pathogenetic aspects. Chest 1993;104:1511–1517.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 04, 2004
Accepted: December 07, 2004
Published online: April 20, 2005
Issue release date: April 2005

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 3

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG


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