Login to MyKarger

New to MyKarger? Click here to sign up.

Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Original Research Article

Free Access

Evaluation of Factors of Importance for Clinical Dementia Diagnosis

Nägga K.a · Garcia J.a, b · Zetterberg H.c · Blennow K.c, d · Gottfries J.e · Marcusson J.a

Author affiliations

aDepartment of Geriatric Medicine, Linköping University Hospital and bClinical Research Centre, Linköping University, Linköping; cDepartment of Clinical Neuroscience, Section of Experimental Neuroscience, University of Göteborg, Sahlgrenska University Hospital, Mölndal; dThe Medical Research Council, and eMedicinal Chemistry, AstraZeneca R&D, Mölndal, Sweden

Corresponding Author

Katarina Nägga, MD

Department of Geriatric Medicine

Linköping University Hospital

SE–58185 Linköping (Sweden)

Tel. +46 13 224093, Fax +46 13 227389, E-Mail Katarina.Nagga@lio.se

Related Articles for ""

Dement Geriatr Cogn Disord 2005;19:289–298

Do you have an account?

Login Information

Contact Information

I have read the Karger Terms and Conditions and agree.


Diagnosing clinical dementia is based on an assessment of different variables, such as the patient’s medical history, known risk factors, and biochemical features. Partial least squares discriminant analysis was used to evaluate variables of importance for diagnosing dementia in a clinical dementia population. Polymorphism for genotypes of glutathione S-transferase (GST) and sulfotransferase 1A1, hypothetically of importance in dementia disorders, was also included in the analysis. The study population consisted of 73 patients with Alzheimer’s disease (AD), 14 with mixed dementia, 75 patients with vascular dementia, and 28 control cases. We found that several of the variables, such as the presence of ApoE4 allele, high cerebrospinal fluid levels of total tau protein, low levels of β-amyloid(1–42), and a low score on the Mini-Mental State Examination, facilitated a discrimination between the diagnoses compared with the controls. The different diagnoses overlapped. There were indications that genotypes of GSTs contributed to a subgrouping within AD.

© 2005 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: November 01, 2004
Published online: April 29, 2005
Issue release date: May 2005

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.