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Original Research Article

Motor Function in Subjects with Mild Cognitive Impairment and Early Alzheimer’s Disease

Pettersson A.F.a, b · Olsson E.a · Wahlund L.-O.b

Author affiliations

Neurotec Department, Divisions of aPhysiotherapy and bClinical Geriatrics, Karolinska Institutet, Stockholm, Sweden

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Dement Geriatr Cogn Disord 2005;19:299–304

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: November 01, 2004
Published online: April 29, 2005
Issue release date: May 2005

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

Basic mobility, balance, gait and dual-task performance were characterised in 140 consecutive subjects referred to a multidisciplinary university hospital in a geriatric setting for cognitive symptoms and possible dementia. After completion of an extensive diagnostic evaluation, subjects were classified into four diagnostic categories: no cognitive impairment, mild cognitive impairment, Alzheimer’s disease (AD) and other dementia. Mean age was 57 ± 9.2, 60 ± 7.3, 68 ± 9.9 and 64 ± 10.5, respectively. Data on motor function, medication use and presence of white matter changes were evaluated and compared between the diagnostic groups. Motor function seems to be affected in very mild AD but not in mild cognitive impairment, as assessed with performance-based tests. AD subjects were slowed and had difficulties in dual-task performance requiring concurrently performing a cognitive task while walking.

© 2005 S. Karger AG, Basel


References

  1. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E: Mild cognitive impairment: Clinical characterization and outcome. Arch Neurol 1999;56:303–308.
  2. Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, et al: Current concepts in mild cognitive impairment. Arch Neurol 2001;58:1985–1992.
  3. Ala TA, Frey WH 2nd: Validation of the NINCDS-ADRDA criteria regarding gait in the clinical diagnosis of Alzheimer disease. A clinicopathologic study. Alzheimer Dis Assoc Disord 1995;9:152–159.
  4. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 1984;34:939–944.
  5. Franssen EH, Reisberg B, Kluger A, Sinaiko E, Boja C: Cognition-independent neurologic symptoms in normal aging and probable Alzheimer’s disease. Arch Neurol 1991;48:148–154.
  6. Funkenstein HH, Albert MS, Cook NR, West CG, Scherr PA, Chown MJ, et al: Extrapyramidal signs and other neurologic findings in clinically diagnosed Alzheimer’s disease. A community-based study. Arch Neurol 1993;50:51–56.
  7. Goldman WP, Baty JD, Buckles VD, Sahrmann S, Morris JC: Motor dysfunction in mildly demented AD individuals without extrapyramidal signs. Neurology 1999;53:956–962.
  8. Kluger A, Gianutsos JG, Golomb J, Ferris SH, George AE, Franssen E, et al: Patterns of motor impairement in normal aging, mild cognitive decline, and early Alzheimer’s disease. J Gerontol B Psychol Sci Soc Sci 1997;52:P28–P39.
  9. O’Keeffe ST, Kazeem H, Philpott RM, Playfer JR, Gosney M, Lye M: Gait disturbance in Alzheimer’s disease: A clinical study. Age Ageing 1996;25:313–316.
  10. Pettersson AF, Engardt M, Wahlund LO: Activity level and balance in subjects with mild Alzheimer’s disease. Dement Geriatr Cogn Disord 2002;13:213–216.
  11. Aguero-Torres H, Thomas VS, Winblad B, Fratiglioni L: The impact of somatic and cognitive disorders on the functional status of the elderly. J Clin Epidemiol 2002;55:1007–1012.
  12. Sauvaget C, Yamada M, Fujiwara S, Sasaki H, Mimori Y: Dementia as a predictor of functional disability: A four-year follow-up study. Gerontology 2002;48:226–233.
  13. Thomas VS: Excess functional disability among demented subjects? Findings from the Canadian Study of Health and Aging. Dement Geriatr Cogn Disord 2001;12:206–210.
  14. Ballard CG, Shaw F, Lowery K, McKeith I, Kenny R: The prevalence, assessment and associations of falls in dementia with Lewy bodies and Alzheimer’s disease. Dement Geriatr Cogn Disord 1999;10:97–103.
  15. Jensen J, Nyberg L, Gustafson Y, Lundin-Olsson L: Fall and injury prevention in residential care–effects in residents with higher and lower levels of cognition. J Am Geriatr Soc 2003;51:627–635.
  16. Melton LJ, 3rd, Beard CM, Kokmen E, Atkinson EJ, O’Fallon WM: Fracture risk in patients with Alzheimer’s disease. J Am Geriatr Soc 1994;42:614–619.
  17. Morris JC, Rubin EH, Morris EJ, Mandel SA: Senile dementia of the Alzheimer’s type: An important risk factor for serious falls. J Gerontol 1987;42:412–417.
  18. Wade DT, Langton Hewer R: Stroke: Associations with age, sex, and side of weakness. Arch Phys Med Rehabil 1986;67:540–545.
  19. Turnbull JC, Kersten P, Habib M, McLellan L, Mullee MA, George S: Validation of the Frenchay Activities Index in a general population aged 16 years and older. Arch Phys Med Rehabil 2000;81:1034–1038.
  20. Berg KO, Wood-Dauphinee SL, Williams JI, Maki B: Measuring balance in the elderly: Validation of an instrument. Can J Public Health 1992;83(suppl 2):S7–S11.
  21. Berg KO, Maki BE, Williams JI, Holliday PJ, Wood-Dauphinee SL: Clinical and laboratory measures of postural balance in an elderly population. Arch Phys Med Rehabil 1992;73:1073–1080.
  22. Berg K, Wood-Dauphinee S, Williams JI: The Balance Scale: Reliability assessment with elderly residents and patients with an acute stroke. Scand J Rehabil Med 1995;27:27–36.
  23. Tinetti ME, Richman D, Powell L: Falls efficacy as a measure of fear of falling. J Gerontol 1990;45:P239–P243.
  24. Hellstrom K, Lindmark B, Fugl-Meyer A: The Falls-Efficacy Scale, Swedish version: Does it reflect clinically meaningful changes after stroke? Disabil Rehabil 2002;24:471–481.
  25. Podsiadlo D, Richardson S: The timed ‘Up & Go’: A test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 1991;39:142–148.
  26. Lundin-Olsson L, Nyberg L, Gustafson Y: Attention, frailty, and falls: The effect of a manual task on basic mobility. J Am Geriatr Soc 1998;46:758–761.
  27. Camicioli R, Howieson D, Lehman S, Kaye J: Talking while walking: The effect of a dual task in aging and Alzheimer’s disease. Neurology 1997;48:955–958.
  28. Tinetti ME: Performance-oriented assessment of mobility problems in elderly patients. J Am Geriatr Soc 1986;34:119–126.
  29. Shumway-Cook A, Baldwin M, Polissar NL, Gruber W: Predicting the probability for falls in community-dwelling older adults. Phys Ther 1997;77:812–819.
  30. Schroter A, Mergl R, Burger K, Hampel H, Moller HJ, Hegerl U: Kinematic analysis of handwriting movements in patients with Alzheimer’s disease, mild cognitive impairment, depression and healthy subjects. Dement Geriatr Cogn Disord 2003;15:132–142.
  31. Murphy SL, Williams CS, Gill TM: Characteristics associated with fear of falling and activity restriction in community-living older persons. J Am Geriatr Soc 2002;50:516–520.
  32. Guralnik JM, Ferrucci L: Assessing the building blocks of function: Utilizing measures of functional limitation. Am J Prev Med 2003;25(3 suppl 2):112–121.
  33. Koutsavlis AT, Wolfson C: Elements of mobility as predictors of survival in elderly patients with dementia: Findings from the Canadian Study of Health and Aging. Chronic Dis Can 2000;21:93–103.
  34. Steffen TM, Hacker TA, Mollinger L: Age- and gender-related test performance in community-dwelling elderly people: Six-Minute Walk Test, Berg Balance Scale, Timed Up & Go Test, and gait speeds. Phys Ther 2002;82:128–137.
  35. Briley DP, Wasay M, Sergent S, Thomas S: Cerebral white matter changes (leukoaraiosis), stroke, and gait disturbance. J Am Geriatr Soc 1997;45:1434–1438.
  36. Pantoni L, Garcia JH: The significance of cerebral white matter abnormalities 100 years after Binswanger’s report. A review. Stroke 1995;26:1293–1301.
  37. Boyle PA, Cohen RA, Paul R, Moser D, Gordon N: Cognitive and motor impairments predict functional declines in patients with vascular dementia. Int J Geriatr Psychiatry 2002;17:164–169.
  38. Verghese J, Lipton RB, Hall CB, Kuslansky G, Katz MJ, Buschke H: Abnormality of gait as a predictor of non-Alzheimer’s dementia. N Engl J Med 2002;347:1761–1768.
  39. Brach JS, VanSwearingen JM, Newman AB, Kriska AM: Identifying early decline of physical function in community-dwelling older women: performance-based and self-report measures. Phys Ther 2002;82:320–328.

Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: November 01, 2004
Published online: April 29, 2005
Issue release date: May 2005

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM


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