Pharmacology and Treatment
A Two-Compound Product Containing Calcipotriol and Betamethasone Dipropionate Provides Rapid, Effective Treatment of Psoriasis vulgaris regardless of Baseline Disease Severityvan de Kerkhof P.C.M.a · Wasel N.b · Kragballe K.d · Cambazard F.e · Murray S.c
aUniversity Hospital Nijmegen, Nijmegen, The Netherlands; bDivision of Dermatology and Cutaneous Sciences, University of Alberta, Edmonton, and cDivision of Dermatology, Dalhousie University, Halifax, Canada; dMarselisborg Hospital, Århus, Denmark; eService de Dermatologie, Hopital Nord, Saint-Etienne, France
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Background: A two-compound product containing calcipotriol and betamethasone dipropionate (Daivobet®/Dovobet®) has been evaluated in a large clinical trial programme, providing a wealth of data on the treatment of psoriasis vulgaris. Objective: To determine the effectiveness of the two-compound product in patients with mild, moderate and severe psoriasis vulgaris. Methods: Data from over 1,534 patients with psoriasis vulgaris who received the two-compound product once daily for at least 4 weeks in four randomised, double-blind studies were pooled. A meta-analysis of the pooled data is presented. Severity of psoriasis at baseline was determined by investigator assessment and Psoriasis Area and Severity Index (PASI) score. Results: For patients with severe disease defined by PASI score (PASI baseline ≧17), the mean reduction in PASI after up to 4 weeks of treatment was 71.6% compared with 68.9 and 67.2% for those with moderate (PASI baseline 5.1–16.0) and mild disease (PASI baseline ≤5). Corresponding reductions for investigator-assessed severity were 72.6, 69.1 and 68.7%, respectively. Conclusion: Although the meta-analysis of the data from these four studies was performed post hoc, we may conclude that the two-compound product provided highly effective treatment of psoriasis, regardless of the category of baseline disease severity.
© 2005 S. Karger AG, Basel
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