Surfactant Protein A Detection in Primary Pulmonary Adenocarcinoma without Bronchioloalveolar PatternUzaslan E.a · Stuempel T.a · Ebsen M.a · Freudenberg N.b · Nakamura S.d · Costabel U.c · Guzman J.a
aGeneral and Experimental Pathology, University of Bochum, Bochum, bDepartment of Cytology, Institute of Pathology, University of Freiburg i. Br., Freiburg i. Br., cDepartment of Pneumology and Allergy, Ruhrlandklinik, Essen, Germany; dDepartment of General Medicine and Clinical Investigation, Nara Medical University, Nara, Japan
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Background: Immunohistochemical studies in human lung carcinoma reported positive staining of tumor cells for surfactant protein A (SP-A), especially in peripheral airway cell carcinoma, which include bronchioloalveolar carcinoma and in some reports also papillary subtypes. Objective: The purpose of this study was to determine the SP-A expression in tumor cells of lung adenocarcinoma without a bronchioloalveolar pattern, classified according to the WHO. Methods: In total, 169 primary adenocarcinomas of the lung (109 acinar, 32 solid with mucin, 24 papillary and 4 mucinous) were examined by immunohistochemistry for SP-A expression. Results: Twenty-five percent of acinar, 38% of papillary and 3% of solid adenocarcinoma with mucin showed a positive intracytoplasmic SP-A reaction of the tumor cells. None of the mucinous adenocarcinomas stained for SP-A. This study included the largest number of acinar adenocarcinomas and solid adenocarcinomas with mucin studied for SP-A. We clearly demonstrated that also primary lung adenocarcinoma without a bronchioloalveolar pattern can express SP-A. A positive staining of hyperplastic type II cells surrounding the tumors or entrapped in the tumor could clearly be differentiated from the SP-A-positive stain of tumor cells. Conclusion: These results support the theory that SP-A-producing cells may generate not only bronchioloalveolar and papillary carcinoma, but also other subtypes of lung adenocarcinoma.
© 2005 S. Karger AG, Basel
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