European Surgical Research
Original Paper
Effect of Fibrin Glue on Small and Large Bowel Anastomoses in the RatShinohara K.a · Kobayashi E.a,b · Yoshida T.a,b · Toyama N.a · Kiyozaki H.a · Fujimura A.b · Miyata M.aa Department of Surgery, Omiya Medical Center, Jichi Medical School, Omiya, and b Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan
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Article / Publication Details
Published online: January 21, 1998
Issue release date: January – February
Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1
ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)
For additional information: https://www.karger.com/ESR
Abstract
Fibrin glue has been used as a hemostatic and adhesive agent for many years, but its efficacy in digestive surgery is still controversial. In this study, we evaluated the effect of fibrin glue on the healing of the small and large bowel anastomotic portions by measurement of the anastomotic bursting pressure. Further, the efficacy of fibrin glue in preventing intra-abdominal adhesion formation was assessed. Our results indicated that fibrin glue enhanced the resistance towards an elevation of intraluminal pressure in small bowel, but not in large bowel. Concomitantly, the glue did not significantly attenuate postoperative adhesion formation. A sealing action of fibrin glue might protect against bleeding and microleakage, resulting in beneficial effects on small bowel anastomosis.
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References
- Scheele J, Herzog J, Mühe E: Fibrin glue protection of digestive anastomoses. Zentralbl Chir 1978;103:1325–1336.
- Athanasiadis S, Kuhlgatz Ch, Girona I: Additional fibrin glueing in surgery of colon and rectum. Zentralbl Chir 1984;109:1107–1111.
- Houston KA, Rotstein OD: Fibrin sealant in high-risk anastomoses. Arch Surg 1988;123:230–234.
-
Spotnitz WD, Dalton MS, Baker JW, et al: Successful use of fibrin glue during 2 years of surgery at a University Medical Center. Am Surg 1989;3:166–171.
- van der Ham AC, Kort WJ, Weijima IM, et al: The effect of fibrin sealant on the healing colonic anastomosis in the rat. Br J Surg 1991;78:49–53.
- van der Ham AC, Kort WJ, Weijima IM, et al: Effect of antibiotics in fibrin sealant on healing colonic anastomoses in the rat. Br J Surg 1992;79:525–528.
- van der Ham AC, Kort WJ, Weijma IM, et al: Transient protection of incomplete colonic anastomoses with fibrin sealant: An experiment study in the rat. J Surg Res 1993;55:256–260.
- Lasa CI Jr, Kidd RR III, Nunez HA, et al: Effect of fibrin glue and opsite on open wounds in DB/DB mice. J Surg Res 1993;54:202–206.
-
Tabata S, Eckert HG, Kellner HM, Hayashi S, Fujimoto K: Pharmacokinetic study of a fibrin adhesive agent, Beriplast® in rats. Oyo Yakuri 1986;31:1123–1127.
- Borst HG, Haverich A, Walterbusch G, Maatz W: Fibrin adhesive: An important hemostatic adjunct in cardiovascular operations. J Thorac Cardiovasc Surg 1982;84:548–553.
- Lng RD, Saxe J, Hendrick S, et al: Antibiotic-primed fibrin gel improves outcome in contaminated splenic injury. J Trauma 1992;33:118–120.
-
Hulkko OA, Haukipuro KA, Laitinen ST, et al: Fibrin glue protection of primary anastomosis in the obstructed left colon. An experimental study on the rat. Acta Chir Scand 1988;151:49–52.
- Dvorak HF, Harvey VS, Estrella P, et al: Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing. Lab Invest 1987;57:673–686.
- Hedelin H, Lundholm K, Teger-Nilsson AC, et al: Influence of local fibrin deposition on granulation tissue formation. A biochemical study in the rat. Eur Surg Res 1983;15:312–316.
- Ketch LL, Buerk CA, Liechty RD: Surgical implications of Behçet’s disease. Arch Surg 1980;115:759–760.
Article / Publication Details
Published online: January 21, 1998
Issue release date: January – February
Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1
ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)
For additional information: https://www.karger.com/ESR
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