Late Development of Diabetes mellitus after Interferon-Alfa and Ribavirin Therapy for Chronic Hepatitis C: A Case ReportRadhakrishnan S.a · Upadhyay A.a · Mohan N.a · Dhar A.a · Walia H.a · Zubaidi G.b
Departments of aGastroenterology and bEndocrinology, The Royal Hospital, Muscat, Oman
Dr. S. Radhakrishnan, FRCP (Edin)
The Royal Hospital, PO Box 1331, CPO 111
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Objective: To report the late development of immune-mediated diabetes mellitus after completion of alfa-interferon therapy for hepatitis C in an Asian patient. Clinical Presentation and Intervention: A 50-year-old male with chronic hepatitis C received treatment with alfa-interferon and ribavirin for 52 weeks. He developed immune-mediated diabetes mellitus with low C-peptide and positive antiglutamic acid decarboxylase antibody after completion of therapy. The hepatitis C infection was eradicated, but he continued to be diabetic requiring insulin therapy during the follow-up. Conclusion: This report shows thatimmune-mediateddiabetes mellitus can occur as a late complication of alfa-interferon therapy.
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