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Regular Article

Effects of Mind-Body Therapy on Quality of Life and Neuroendocrine and Cellular Immune Functions in Patients with Ulcerative Colitis

Elsenbruch S.a1 · Langhorst J.b1 · Popkirowa K.a · Müller T.b · Luedtke R.c · Franken U.b · Paul A.b · Spahn G.b · Michalsen A.b · Janssen O.E.d · Schedlowski M.a, e · Dobos G.b

Author affiliations

aDepartement of Medical Psychology, University Clinic of Essen; bClinic for Internal and Integrative Medicine, Kliniken Essen Mitte; cKarl und Veronica Carstens-Stiftung, dDivision of Endocrinology, University Clinic of Essen, Essen, Germany; eDivision of Psychology and Behavioral Immunobiology, Swiss Federal Institute of Technology, ETH-Zürich, Zürich, Switzerland

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Psychother Psychosom 2005;74:277–287

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Article / Publication Details

First-Page Preview
Abstract of Regular Article

Published online: August 10, 2005
Issue release date: August 2005

Number of Print Pages: 11
Number of Figures: 3
Number of Tables: 4

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: https://www.karger.com/PPS

Abstract

Background: The aim of this study was to investigate the effects of mind-body therapy on neuroendocrine and cellular immune measures, health-related quality of life and disease activity in patients with ulcerative colitis (UC) in remission. Methods: Thirty UC patients in remission or with low disease activity were randomly assigned to an intervention group (n = 15) or a usual-care waiting control group (n = 15). Intervention consisted of a structured 60-hour training program over 10 weeks which included stress management training, moderate exercise, Mediterranean diet, behavioral techniques and self-care strategies. Quality of life, perceived stress and disease activity were assessed with standardized questionnaires (IBDQ, SF-36, PSS, CAI). In addition, the distribution of circulating lymphocytes and lymphocyte subsets as well as the β-adrenergic modulation of TNF-α production in vitro were analyzed. Urine catecholamines and plasma cortisol, prolactin and growth hormone were measured pre- and postinterventionally, and were compared with a healthy control group (n = 10). Results: In response to therapy, patients in the intervention group showed significantly greater improvement in the SF-36 scale Mental Health and the Psychological Health Sum score compared with changes observed in the usual-care waiting control group. Patients in the intervention group showed significantly greater improvement on the IBDQ scale Bowel Symptoms compared with the control group. However, no significant group differences in circulating lymphocyte subsets or endocrine parameters were observed in response to therapy. In addition, no significant effects of intervention on either the basal levels of TNF-α or the suppressive action of the β-adrenergic agonist isoproterenol on TNF-α production were observed. Conclusion: Mind-body therapy may improve quality of life in patients with UC in remission, while no effects of therapy on clinical or physiological parameters were found, which may at least in part be related to selective patient recruitment.

© 2005 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Regular Article

Published online: August 10, 2005
Issue release date: August 2005

Number of Print Pages: 11
Number of Figures: 3
Number of Tables: 4

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: https://www.karger.com/PPS


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