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Original Article

Impact of Menopause on the Augmentation of Arterial Stiffness with Aging

Takahashi K.a · Miura S.a · Mori-Abe A.a · Kawagoe J.a · Takata K.a · Ohmichi M.b · Kurachi H.a

Author affiliations

aDepartment of Obstetrics and Gynecology, Yamagata University School of Medicine, Yamagata, and bDepartment of Obstetrics and Gynecology, Osaka University Medical School, Suita, Osaka, Japan

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Gynecol Obstet Invest 2005;60:162–166

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: February 04, 2005
Accepted: March 15, 2005
Published online: October 06, 2005
Issue release date: October 2005

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 2

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI

Abstract

Background/Aims: Aortic stiffness, determined by pulse wave velocity (PWV), is an independent marker of cardiovascular risk. PWV is mainly influenced by age-associated alterations in arterial wall structure and blood pressure. The present study was conducted to assess the impact of menopause on the brachial-ankle PWV (baPWV) in healthy women. Methods: Fifty premenopausal women aged 22–54 years and 40 postmenopausal women aged 40–73 years were recruited for this study. Subjects with hypertension, diabetes, and hyperlipidemia were strictly excluded. The results of baPWV were analyzed chronologically by 10- or 5-year age intervals. Results: There was no significant difference in baPWV between premenopausal and postmenopausal women in their 40s and 50s. The baPWV of postmenopausal women aged over 60 years was significantly higher than that of postmenopausal women in their 50s. To clarify the age-dependent elevation in baPWV in detail, women their 50s and 60s were divided into subgroups by 5-year age intervals. There was no significant difference in baPWV among the 50–54-, 55–59- and 60–64-year subgroups. baPWV significantly increased in the 65–69- year subgroup (p< 0.05). There was a significant relationship between baPWV and age in premenopausal (r = 0.452, p = 0.001) and postmenopausal (r = 0.581, p < 0.0001) women. The slope of the regression line for baPWV plotted against age was steeper in postmenopausal than in premenopausal women. Conclusions: This study produces suggestive evidence that menopause amplifies the age-dependent increase in arterial stiffness.

© 2005 S. Karger AG, Basel


References

  1. Kannel WB, Hjortland MC, McNamara PM, Gordon T: Menopause and risk of cardiovascular disease: The Framingham study. Ann Intern Med 1976;85:447–452.
  2. Gordon T, Kannel WB, Hjortland MC, McNamara PM: Menopause and coronary heart disease. The Framingham Study. Ann Intern Med 1978;89:157–161.
  3. van der Schouw YT, van der Graaf Y, Steyerberg EW, Eijkemans JC, Banga JD: Age at menopause as a risk factor for cardiovascular mortality. Lancet 1996;347:714–718.
  4. Staessen JA, Ginocchio G, Thijs L, Fagard R: Conventional and ambulatory blood pressure and menopause in a prospective population study. J Hum Hypertens 1997;11:507–514.
  5. Staessen JA, van der Heijden-Spek JJ, Safar ME, Den Hond E, Gasowski J, Fagard RH, Wang JG, Boudier HA, Van Bortel LM: Menopause and the characteristics of the large arteries in a population study. J Hum Hypertens 2001;15:511–518.
  6. Blacher J, Guerin AP, Pannier B, Marchais SJ, Safar ME, London GM: Impact of aortic stiffness on survival in end-stage renal stage. Circulation 1999;99:2434–2439.
  7. Yamashina A, Tomiyama H, Takeda K, Tsuda S, Arai T, Hirose K, Koji Y, Hori S, Yamamoto Y: Validity, reproducibility, and clinical significance of non-invasive brachial-ankle pulse wave velocity measurement. Hypertens Res 2002;25:359–364.
  8. Tomiyama H, Yamashina A, Arai T, Hirose K, Koji Y, Chikamori T, Hori S, Yamamoto Y, Doba N, Hinohara S: Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement – A survey of 12,517 subjects. Atherosclerosis 2003;166:303–309.
  9. Rajkumar C, Kingwell BA, Cameron JD, Waddell T, Mehra R, Christophidis N, Komesaroff PA, McGrath B, JenningsGL, Sudhir K, Dart AM: Hormonal therapy increases arterial compliance in postmenopausal women. Am Coll Cardiol 1997;30:350–356.
  10. Teede HJ, Liang YL, Kotsopoulos D, Zoungas S, Cravent R, McGrath BP: A placebo-controlled trial of long-term oral combined continuous hormone replacement therapy in postmenopausal women: Effects on arterial compliance and endothelial function. Clin Endocrinol 2001;55:673–682.
  11. Teede HJ, Liang YL, Kotsopoulos D, Zoungas S, Craven R, McGrath BP: Placebo-controlled trial of transdermal estrogen therapy alone in postmenopausal women: Effects on arterial compliance and endothelial function. Climacteric 2002;5:160–169.
  12. Miura S, Tanaka E, Mori A, Toya M, Takahashi K, Nakahara K, Ohmichi M, Kurachi H: Hormone replacement therapy improves arterial stiffness in normotensive postmenopausal women. Maturitas 2003;45:293–298.
  13. Mendelsohn ME, Karas RH: The protective effects of estrogen on the cardiovascular system. N Engl J Med 1999;340:1801–1811.
  14. Smulyan H, Asmar RG, Rudnicki A, London GM, Safar ME: Comparative effects of aging in men and women on the properties of the arterial tree. J Am Coll Cardiol 2001;37:1374–1380.
  15. Rossouw JE, Anderson GL, Prentice RL, La Croix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J, Writing Group for the Women’s Health Initiative Investigators: Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women’s Health Initiative randomized controlled trial. JAMA 2002;288:321–333.
  16. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E: Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA 1998;280:605–613.
  17. Hodis HN, Mack WJ, Lobo RA, Shoupe D, Sevanian A, Mahrer PR, Selzer RH, Liu CR, Liu CH, Azen SP: Estrogen in the prevention of atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 2001;135:939–953.
  18. Cohn J: Arterial compliance to stratify cardiovascular risk: More precision in therapeutic decision making. Am J Hypertens 2001;14:258s–263s.
    External Resources
  19. Jonason T, Henriksen E, Kangro T, Vessby B, Ringqvist I: Menopause is associated with the stiffness of the common carotid artery in 50-year-old women. Clin Physiol 1998;18:149–155.
  20. Wilkinson IB, Qasem A, McEniery CM, Webb DJ, Avolio AP, Cockcroft JR: Nitric oxide regulates local arterial distensibility in vivo. Circulation 2002;105:213–217.
  21. Hisamoto K, Ohmichi M, Kurachi H, Hayakawa J, Kanda Y, Nishio Y, Adachi K, Tasaka K, Miyoshi E, Fujiwara N, Taniguchi N, Murata Y: Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells. J Biol Chem 2001;276:3459–3467.
  22. Ohmichi M, Kanda Y, Hisamoto K, Morishige K, Takahashi K, Sawada K, Minekawa R, Tasaka K, Murata Y: Rapid changes of flow-mediated dilatation after surgical menopause. Maturitas 2003;44:125–131.
  23. Asmar R, Benetos A, Topouchian J, Laurent P, Pannier B, Brisac AM, Target R, Levy BI: Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies. Hypertension 1995;26:485–490.

Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: February 04, 2005
Accepted: March 15, 2005
Published online: October 06, 2005
Issue release date: October 2005

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 2

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI


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