Dementia and Geriatric Cognitive Disorders

Original Research Article

Functional Disabilities Profile of Chinese Elderly People with Alzheimer’s Disease – A Validation Study on the Chinese Version of the Disability Assessment for Dementia

Mok C.C.M.a · Siu A.M.H.b · Chan W.C.a · Yeung K.M.c · Pan P.C.d · Li S.a

Author affiliations

aPsychogeriatric Department, Castle Peak Hospital, bDepartment of Rehabilitation Science, Hong Kong Polytechnic University, cDepartment of Medicine and Geriatrics, Princess Margaret Hospital, and dUnited Christian Hospital, Hong Kong, SAR, China

Keywords: Alzheimer’s diseaseFunctional disabilitiesDisability Assessment for Dementia

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Dement Geriatr Cogn Disord 2005;20:112–119
https://doi.org/10.1159/000086612

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: February 23, 2005
Published online: August 19, 2005
Issue release date: August 2005

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

This study aimed to determine the validity and applicability of the Chinese version of the Disability Assessment for Dementia (CDAD) in the Chinese elderly population. The original English version was translated and modified to a 47-item scale to suit the societal and cultural background of the Chinese population. The CDAD was administered to 169 community-residing Chinese elderly people with Alzheimer’s disease (AD) and demonstrated high internal consistency (Cronbach’s α = 0.91), excellent test-retest reliability (intraclass correlation, ICC = 0.99) and excellent interrater reliability (ICC = 0.98). The functional disabilities profile of the same sample was examined. The CDAD had a high negative correlation with the Global Deterioration Scale (GDS; Spearman’s ρ = –0.89, p< 0.001). ANOVA and post hoc comparisons showed there were significant differences in the mean CDAD scores across different GDS stages. To study the construct validity, the CDAD was administered concurrently with several instruments. The Instrumental Activities of Daily Living subscore of the CDAD had a high correlation with the Instrumental Activities of Daily Living Scale (r = 0.94,p< 0.001), and the Activities of Daily Living subscore of the CDAD had a high correlation with the Modified Barthel Index (r = 0.82, p < 0.001). A moderate correlation (r = 0.60, p < 0.001) with the Cantonese version of the Mini Mental State Examination was also found. Analysis of the relationship with sociodemographic factors indicated that the CDAD was not correlated with gender and education, and that the correlation with age was low. The CDAD was shown to be a reliable and valid instrument in assessing the functional disabilities of community-residing elderly subjects with AD in the Chinese population.

© 2005 S. Karger AG, Basel



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References

  1. US Department of Health and Human Services: Early Alzheimer’s disease: Recognition and assessment. AHCPR Publication No 97-R123. Agency for Health Care Policy and Research, 1996.
  2. Lobo A, Launer LJ, Fratiglioni L, Andersen K, Di Carlo A, Breteler MMB, Copeland JRM, Dartigues J-F, Jagger C, Martinez-Lage J, Soininen H, Hofman A: Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurology 2000;54(suppl 5):S4–S9.
  3. Chiu HFK, Lam LCW, Chi I, Leung T, Li SW, Law WT, Chung DWS, Fung HHL, Kan PS, Lum CM, Ng J, Lau J: Prevalence of dementia in Chinese elderly in Hong Kong. Neurology 1998;50:1002–1009.
    External Resources
  4. Hong Kong Census and Statistics Department: Hong Kong in Figures. Hong Kong, HKSAR, 2002.
  5. Clarke M, Jagger C, Anderson J, Battcock T, Kelly F, Stern MC: The prevalence of dementia in a total population: A comparison of two screening instruments. Age Ageing 1991;20:396–403.
    External Resources
  6. Borell L: Supporting functional behavior in Alzheimer’s disease. Int Psychogeriatr 1996;8(suppl 1):123–125.
    External Resources
  7. American Psychiatric Association: Diagnostic and statistical manual of mental disorders, ed 4. Washington, American Psychiatric Association, 1994.
  8. Burns A, Lawlor B, Craig S: Assessment Scales in Old Age Psychiatry. London, Dunitz, 1999.
  9. Kempen GIJM, Suurmeijer TPBM: The development of a hierarchical polychotomous ADL-IADL scale for non-institutionalized elders. Gerontologist 1990;30:497–502.
    External Resources
  10. Barberger-Gateau P, Fabrigoule C, Helmer C, Rouch I, Dartigues J-F: Functional impairment in instrumental activities of daily living: An early clinical sign of dementia? J Am Geriatr Soc 1999;47:456–462.
    External Resources
  11. Carswell A, Spiegel R: Functional assessment; in Wilcock GA, Bucks RS, Rockwood K (eds): Diagnosis and Management of Dementia: A Manual for Memory Disorders Teams. New York, Oxford University Press, 1999, pp 158–178.
  12. Lawton MP, Brody EM: Assessment of older people: Self-maintaining and Instrumental Activities of Daily Living. Gerontologist 1969;9:179–186.
    External Resources
  13. Gelinas I, Gauthier L, McIntyre M, Gauthier S: Development of a functional measure for persons with Alzheimer’s disease: The Disability Assessment for Dementia. Am J Occup Ther 1999;53:471–481.
    External Resources
  14. Morris JC, Cyrus PA, Orazem J, Mas JBS, Bieber F, Ruzicka BB, Gulanski B: Metrifonate benefits cognitive, behavioral, and global function in patients with Alzheimer’s disease. Neurology 1998;50:1222–1230.
    External Resources
  15. Dubois B, McKeith I, Orgogozo J-M, Collins O, Meulien D: A multicentre, randomized, double-blind, placebo-controlled study to evaluate the efficacy, tolerability and safety of two doses of metrifonate in patients with mild-to-moderate Alzheimer’s disease: The Malt Study. Int Psychogeriatr 1999;14:973–982.
    External Resources
  16. Raskind MA, Cyrus PA, Ruzicka BB, Gulanski BI: The effects of metrifonate on the cognitive, behavioral, and functional performance of Alzheimer’s disease patients. J Clin Psychiatry 1999;60:318–325.
    External Resources
  17. Farlow MR, Cyrus PA: Metrifonate therapy in Alzheimer’s disease: A pooled analysis of four randomized, double-blind, placebo-controlled trials. Dement Geriatr Cogn Disord 2000;11:202–211.
    External Resources
  18. Gelinas I, Gauthier S, Cyrus PA: Metrifonate enhances the ability of Alzheimer’s disease patients to initiate, organize, and execute instrumental and basic activities of daily living. J Geriatr Psychiatry Neurol 2000;13:9–16.
    External Resources
  19. Raskind MA, Peskind ER, Wessel T, Yuan W, the Galantamine USA-Study Group: Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension. Neurology 2000;54:2261–2268.
    External Resources
  20. Wilcock GK, Lilenfeld S, Gaens E: Efficacy and safety of galantamine in patients with mild to moderate Alzheimer’s disease: Multicentre randomized controlled trial. Br Med J 2000;321:145–149.
    External Resources
  21. Feldman H, Sauter A, Donald A, Gelinas I, Gauthier S, Torfs K, Parys W, Mehnert A: A 12-month study of functional ability in mild to moderate severity Alzheimer disease. Alzheimer Dis Assoc Disord 2001;15:89–95.
    External Resources
  22. Sibley A, MacKnight C, Rockwood K, Fisk J, Gauthier S, Guzman DA, Hogan DB: The effect of the living situation on the severity of dementia at diagnosis. Dement Geriatr Cogn Disord 2002;13:40–45.
    External Resources
  23. Chiu H, Lee HC, Chung WS, Kwong PK: Reliability and validity of the Cantonese version of Mini Mental State Examination – A preliminary study. J Hong Kong Coll Psychiatrists 1994, pp 425–428.
  24. Reisberg B, Ferris SH, De Leon MJ, Crook T: The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry 1982;139:1136–1139.
    External Resources
  25. Shah S, Vanclay F, Cooper B: Improving the sensitivity of the Barthel Index for stroke rehabilitation. J Clin Epidemiol 1989;44:703–709.
    External Resources
  26. Sclan SG, Reisberg B: Functional assessment (FAST) in Alzheimer’s disease: Reliability, validity and ordinality. Int Psychogeriatr 1992;4:55–69.
    External Resources
  27. Green CR, Mohs RC, Schmeidler J, et al: Functional decline in Alzheimer’s disease: A longitudinal study. J Am Geriatr Soc 1993;41:654–661.
    External Resources
  28. Galasko D, Edland SD, Morris JC, Clark C, Mohs R, Koss E: The consortium to establish a registry for Alzheimer’s disease (CERAD). Neurology 1995;45:1451–1455.
    External Resources
  29. Mahurin RK, DeBettignies BH, Pirozzolo FJ: Structured assessment of independent living skills: Preliminary report of a performance measure of functional abilities in dementia. J Gerontol 1991;46:58–66.
  30. Oakley F, Sunderland T, Hill JL, Phillips SL, Makahon R, Ebner JD: The Daily Activities Questionnaire: A functional assessment for people with Alzheimer’s disease. Phys Occup Ther Geriatr 1991;10:67–81.
    External Resources
  31. Carswell A, Eastwood R: Activities of daily living, cognitive impairment and social function in community residents with Alzheimer’s disease. Can J Occup Ther 1993;60:130–136.
  32. Beland F, Aunzunegui MV: Predictors of functional status in older people living at home. Age Ageing 1999;28:153–159.
    External Resources
  33. Hebert R, Brayne C, Spiegelhalter D: Factors associated with functional decline and improvement in a very elderly community-dwelling population. Am J Epidemiol 1999;159:501–510.
    External Resources
  34. Sisson RA: Cognitive status as a predictor of right hemisphere stroke outcomes. J Neurosci Nurs 1995;27:152–156.
    External Resources
  35. Gauthier L, Gauthier S: Assessment of functional changes in Alzheimer’s disease. Neuroepidemiology 1990;9:183–188.
    External Resources

Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: February 23, 2005
Published online: August 19, 2005
Issue release date: August 2005

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

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2005, Vol.20, No. 2-3

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