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Review Article

Meta-Analysis of Trials Comparing Oral Anticoagulation and Aspirin versus Dual Antiplatelet Therapy after Coronary Stenting

Clues for the Management of Patients with an Indication for Long-Term Anticoagulation Undergoing Coronary Stenting

Rubboli A.a · Milandri M.b · Castelvetri C.b · Cosmi B.c

Author affiliations

aCardiac Catheterization Laboratory, Division of Cardiology, bDivision of Internal Medicine E, Maggiore Hospital, and cDivision of Angiology, S. Orsola-Malpighi University Hospital, Bologna, Italy

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Cardiology 2005;104:101–106

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Article / Publication Details

First-Page Preview
Abstract of Review Article

Received: November 09, 2004
Accepted: January 16, 2005
Published online: August 24, 2005
Issue release date: August 2005

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

The combination of oral anticoagulation (OAC) and aspirin was the antithrombotic treatment initially adopted after coronary stenting (PCI-S). Although dual antiplatelet therapy with aspirin and a thienopyridine subsequently proved safer and more effective, OAC and aspirin combination is still used in patients with an indication for long-term OAC undergoing PCI-S. The absolute (AR) and relative (RR) risk of cardiac events and hemorrhagic/vascular complications of OAC and aspirin versus antiplatelet therapy were evaluated in a meta-analysis of four historical clinical trials. In 2,436 patients, the RR of a 30-day primary composite endpoint of death, myocardial infarction and the need for revascularization was significantly reduced by antiplatelet therapy (RR 0.41; 95% CI 0.25–0.69), whereas the RR of stent thrombosis (RR 0.26; 95% CI 0.06–1.14) and major bleeding (RR 0.36; 95% CI 0.14–1.02) was not statistically different. The 30-day AR of death, myocardial infarction, need for revascularization, major bleedings and vascular complications with OAC and aspirin were 0.65, 3.8, 4.2, 6.4 and 6.6%, respectively. In conclusion, due to the low AR of adverse events, the combination of OAC and aspirin appears an acceptable treatment after PCI-S in patients in whom long-term OAC is deemed mandatory.

© 2005 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review Article

Received: November 09, 2004
Accepted: January 16, 2005
Published online: August 24, 2005
Issue release date: August 2005

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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