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Original Paper

Free Access

Linkage Disequilibrium Inflates Type I Error Rates in Multipoint Linkage Analysis when Parental Genotypes Are Missing

Boyles A.L. · Scott W.K. · Martin E.R. · Schmidt S. · Li Y.-J. · Ashley-Koch A. · Bass M.P. · Schmidt M. · Pericak-Vance M.A. · Speer M.C. · Hauser E.R.

Author affiliations

Center for Human Genetics, Duke University Medical Center, Durham, N.C., USA

Corresponding Author

Elizabeth R. Hauser, PhD

Duke University Medical Center

Box 3445

Durham, NC 27710 (USA)

Tel. +1 919 684 2063, Fax +1 919 684 2275, E-Mail Elizabeth.Hauser@duke.edu

Related Articles for ""

Hum Hered 2005;59:220–227

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Abstract

Objectives: Describe the inflation in nonparametric multipoint LOD scores due to inter-marker linkage disequilibrium (LD) across many markers with varied allele frequencies. Method: Using simulated two-generation families with and without parents, we conducted nonparametric multipoint linkage analysis with 2 to 10 markers with minor allele frequencies (MAF) of 0.5 and 0.1. Results: Misspecification of population haplotype frequencies by assuming linkage equilibrium caused inflated multipoint LOD scores due to inter-marker LD when parental genotypes were not included. Inflation increased as more markers in LD were included and decreased as markers in equilibrium were added. When marker allele frequencies were unequal, the r2 measure of LD was a better predictor of inflation than D′. Conclusion: This observation strongly supports the evaluation of LD in multipoint linkage analyses, and further suggests that unaccounted for LD may be suspected when two-point and multipoint linkage analyses show a marked disparity in regions with elevated r2 measures of LD. Given the increasing popularity of high-density genome-wide SNP screens, inter-marker LD should be a concern in future linkage studies.

© 2005 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 19, 2004
Accepted: May 06, 2005
Published online: August 19, 2005
Issue release date: August 2005

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE


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