Low-Dose Vitamin D Prevents Muscular Atrophy and Reduces Falls and Hip Fractures in Women after Stroke: A Randomized Controlled TrialSato Y.a · Iwamoto J.b · Kanoko T.c · Satoh K.d
aDepartment of Neurology, Futase Social Insurance Hospital, Iizuka; bDepartment of Sport Medicine, Keio University School of Medicine, Tokyo; Departments of cRehabilitation Medicine and dVascular Biology, Hirosaki University School of Medicine, Hirosaki, Japan
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- Ramnemark A, Nilsson M, Borssén B, Gustafson Y: Stroke, a major and increasing risk factor for femoral neck fracture. Stroke 2000;31:1572–1577.
- Sato Y, Kaji M, Oizumi K: Vitamin D deficiency and the risk of hip fractures among disabled elderly stroke patients. Stroke 2001;32:1673–1677.
- Lamb SE, Ferrucci L, Volapto S, Fried LP, Guralnik JM: Risk factors for falling in home-dwelling older women with stroke: the Women’s Health and Aging Study. Stroke 2003;34:494–501.
- Teasell R, McRae M, Foley N, Bhardwaj A: The incidence and consequences of falls in stroke patients during inpatient rehabilitation: factors associated with high risk. Arch Phys Med Rehabil 2002;83:329–333.
- Bischoff HA, Dawson-Hughes B, Willett WC, Staehelin HB, Robert Y, Zee RY, Wong JB: Effect of vitamin D on falls. A meta-analysis. JAMA 2004;291:1999–2006.
- Dawson-Hughes B, Harris SS, Krall EA, Dallal GE: Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 1997;337:670–676.
- Bischoff HA, Stahelin HB, Dick W, Dick W, Akos R, Knecht M: Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 2003;18:343–351.
- Bischoff HA, Borchers M, Gudat F, Duermueller U, Theiler R, Stahelin HB, Dick W: In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J 2001;33:19–24.
- Sato Y, Maruoka H, Oizumi K, Kikuyama M: Vitamin D deficiency and osteopenia in the hemiplegic limbs of stroke patients. Stroke 1996;27:2183–2187.
- Mahoney FI, Barthel DW: Functional evaluation: The Barthel index. Md St Med J 1965;14:61–65.
Scandinavian Stroke Study Group: Multicenter trial of hemodilution in ischemic stroke – Background and study protocol. Stroke 1985;16:885–890.
- Komar L, Nieves J, Cosman F, Rubin A, Shen V, Lindsay R: Calcium homeostasis of an elderly population upon admission to a nursing home. J Am Geriatr Soc 1993;41:1057–1064.
Medical Research Coucil of the United Kingdom. Aids to the Examination of the Peripheral Nervous System. London, Pendragon House, 1978.
Dubowitz V: Definition of pathological changes seen in muscle biopsies; in Dubowitz V (ed): Muscle Biopsy. A Practical Approach. London, Ballière Tindal, 1985, p 90.
Cox DR, Hinckley DV: Theoretical Statistics. London, Champan and Hall, 1974, p 94.
- Sato Y, Kaji M, Tsuru T, Oizumi K: Risk factors for hip fracture among elderly patients with Parkinson’s disease. J Neurol Sci 2001;82:89–93.
- Gallagher JC, Fowler SE, Detter JR, Sherman SS: Combination treatment with estrogen and calcitriol in the prevention of age-related bone loss. J Clin Endocrinol Metab2001;86:3618–3628.
- Pfeifer M, Begerow B, Minne HW, Abrams C, Nachtigall D, Hansen C: Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res 2000;15:1113–1118.
- Stein MS, Wark JD, Scherer SC, Walton SL, Chick P, Di Carlantonio M, Zajac JD, Flicker L: Falls relate to vitamin D and parathyroid hormone in an Australian nursing home and hostel. J Am Geriatr Soc 1999;47:1195–1201.
- Bischoff HA, Stähelin HB, Urscheler N, Ehrsam R, Vonthein R, Perrig-Chiello P, Tyndall A, Theiler R: Muscle strength in the elderly: its relation to vitamin D metabolites. Arch Phys Med Rehabil 1999;80:54–58.
- Sorensen OH, Lund B, Saltin B, Lund B, Andersen RB, Hjorth L, Melsen F, Mosekilde L: Myopathy in bone loss of ageing: improvement by treatment with 1 alpha-hydroxycholecalciferol and calcium. Clin Sci (Lond) 1979;56:157–161.
- Russell JA: Osteomalacic myopathy. Muscle Nerve 1994;17:578–580.
- Simpson RU, Thomas GA, Arnold AJ: Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle. J Biol Chem 1985;260:8882–8891.
- Costa EM, Blau HM, Feldman D: 1,25-dihydroxyvitamin D3 receptors and hormonal responses in cloned human skeletal muscle cells. Endocrinology 1986;119:2214–2220.
- Haddad JG, Walgate J, Min C, Hahn TJ: Vitamin D metabolite-binding proteins in human tissue. Biochim Biophys Acta 1976;444:921–925.
- Boland R: Role of vitamin D in skeletal muscle function. Endocr Rev 1986;7:434–747.
- McKenna MJ: Differences in vitamin D status between countries in young adults and the elderly. Am J Med 1992;93:69–77.
- Davies M, Mawer EB, Hann JT, Taylor JL: Seasonal changes in the biochemical indices of vitamin D deficiency in the elderly: a comparison of people in residential homes, long-stay wards and attending a day hospital. Age Ageing 1986;15:77–783.
- Bischoff H, Stähelin HB, Vogt P, Friderich P, Vonthein R, Tyndall A, Theiler R: Immobility as a major cause of bone remodeling in residents of a long-stay geriatric ward. Calcif Tissue Int 1999;64:485–489.
- Eastwood JB, Stamp TC, De Wardener HE, Bordier PJ, Arnaud CD: The effect of 25-hydroxy vitamin D3 in the osteomalacia of chronic renal failure. Clin Sci Mol Med 1977;52:499–508.
Stern G, Thonchin M, Smith R: Muscular weakness in metabolic bone disease. Neurology 1973;20:480–483.
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