Dementia and Geriatric Cognitive Disorders

Original Research Article

Determinants of Prestroke Cognitive Impairment in Stroke Associated with Small Vessel Disease

Mok V.a · Wong A.a · Tang W.K.b · Lam W.W.M.c · Fan Y.H.a · Richards P.S.c · Wong K.T.c · Ahuja A.T.c · Wong K.S.a

Author affiliations

Departments of aMedicine and Therapeutics, bPsychiatry and cRadiology and Organ Imaging, the Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China

Keywords: Prestroke cognitive impairmentStrokeSmall vessel disease

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Dement Geriatr Cogn Disord 2005;20:225–230
https://doi.org/10.1159/000087310

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: January 29, 2005
Published online: September 12, 2005
Issue release date: September 2005

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

Understanding the determinants of prestroke cognitive impairment (PCI) in stroke associated with small vessel disease (SVD) may shed light on how to prevent further cognitive deterioration after stroke. We administered the Informant Questionnaire on Cognitive Decline (IQCODE) to close informants of 78 consecutive stroke patients who had SVD. PCI, as defined by an average score of IQCODE ≧3.4 was found in 19 (24%) patients. Regression analyses were performed on the following risk factors for PCI: age, years of education, gender, previous stroke, volume of white matter changes, measures of silent lacunes, cerebral atrophy index, medial temporal lobe atrophy and frontal lobe atrophy. Multivariate regression analyses revealed that only cerebral atrophy index (OR 1.5, CI 1.2–1.9, p < 0.001) predicted PCI among patients with SVD.

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: January 29, 2005
Published online: September 12, 2005
Issue release date: September 2005

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

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2005, Vol.20, No. 4

September 2005

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