European Surgical Research
Original Paper
Effects of Re-Arterialization on Early Graft Function and Regeneration in the Rat Model of Heterotopic Auxiliary Liver TransplantationFan Y.-D.a · Praet M.b · Vanzieleghem B.c · Vanwynsberghe D.a · Stoop D.a · Leroux-Roels G.d · Delanghe J.d · de Hemptinne B.aaDivision of Experimental Surgery, Department of Surgery, Departments of bPathology, cRadiology and dClinical Chemistry, Microbiology and Immunology, University Hospital of Ghent, Belgium
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Eur Surg Res 2000;32:11–17
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Article / Publication Details
First-Page Preview
Published online: March 10, 2000
Issue release date: January – February
Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 1
ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)
For additional information: https://www.karger.com/ESR
Abstract
In the rat model of heterotopic auxiliary liver transplantation, graft re-arterialization may influence the outcome of inter-liver competition. This was investigated in the current study using two transplanted groups with or without graft re-arterialization. Immediately after reperfusion, the re-arterialized grafts showed significantly higher bile flow rate and bilirubin excretion than the grafts without re-arterialization. DNA synthesis rate was also increased more drastically in the re-arterialized group following the transplantation. Without re-arterialization, the rats developed more pronounced cytolysis and cholestasis. Among the long-term survivors, all healthy re-arterialized grafts regenerated, whereas 5/6 non-re-arterialized grafts atrophied. These data demonstrate that the re-arterialization increases graft survival by improving early hepatic function, enhancing regenerative response and preventing post-transplant biliary complications in this rat model.
© 2000 S. Karger AG, Basel
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Article / Publication Details
First-Page Preview
Published online: March 10, 2000
Issue release date: January – February
Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 1
ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)
For additional information: https://www.karger.com/ESR
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