European Surgical Research

Original Paper

Beneficial Effects of Prostaglandin E1 Incorporated in Lipid Microspheres on Liver Injury and Regeneration after 90% Partial Hepatectomy in Rats

Ando K. · Miyazaki M. · Shimizu H. · Okuno A. · Nakajima N.

Author affiliations

First Department of Surgery, School of Medicine, Chiba University, Chiba, Japan

Keywords: ProstaglandinLiver regenerationHepatectomyLiver injuryEndotoxin

Related Articles for ""
Eur Surg Res 2000;32:155–161
https://doi.org/10.1159/000008757

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: July 06, 2000
Issue release date: May – June

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 4

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR

Abstract

The aim of this study was to assess how the administration of prostaglandin E1 incorporated in lipid microspheres (Lipo PGE1) affects liver injury and regeneration after massive hepatectomy in rats. Two hundred and eight male Wistar rats underwent 90% partial hepatectomy. Lipo PGE1 of 1, 10 or 30 μg/kg were administered intraperitoneally at 6 h prior to and 0 and 6 h after hepatectomy. Postoperative increases in serum GOT, total bilirubin, IL-6 and plasma endotoxin levels were significantly suppressed by Lipo PGE1. The depressed phagocytic index and arterial ketone body ratio and hepatic DNA synthesis after 90% partial hepatectomy were significantly enhanced by Lipo PGE1, which resulted in the improvement of survival. Lipo PGE1 might bring about a protective effect on liver injury and an enhancement of liver regeneration after massive hepatectomy.

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: July 06, 2000
Issue release date: May – June

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 4

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR

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2000, Vol.32, No. 3

May – June

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