Mast Cells in Allergic Diseases
Editor(s): Saito, H. (Tokyo)Okayama, Y. (Yokohama)
Mast Cell-Derived Cytokine Expression Induced via Fc Receptors and Toll-Like ReceptorsOkayama Y.Laboratory for Allergy Transcriptome, RIKEN Research Center for Allergy and Immunology, Yokohama City, Kanagawa, Japan
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Article / Publication Details
Published online: August 15, 2005
Cover Date: 2005
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISBN: 978-3-8055-7948-3 (Print)
eISBN: 978-3-318-01232-3 (Online)
Abstract
It is now well established that human mast cells (MCs) are a source of several multifunctional cytokines. Preformed immunoreactive tumor necrosis factor-α (TNF-α) has been observed within human skin, and pulmonary MC granules are released after IgE-dependent activation. Recent studies in animal models indicate that mouse MCs may play a protective role in host defense against bacteria through production of TNF-α, mainly as a result of Tolllike receptor 4 (TLR4)- or CD48-mediated activation. Moreover, several recent observations in animal models have indicated that MCs may also play a pivotal role in coordinating the early phases of autoimmune diseases through production of TNF-α, particularly as a result of FcγRIII-mediated activation by autoantibodies. The questions now concern how MCs modulate immune responses and what cytokines MCs release through activation of each receptor. Since we recently identified functional TLR4 and FcγRI on human MCs, in this study we used high-density oligonucleotide probe arrays (GeneChip) to compare each of the receptormediated gene expression profiles with the FcεRI-mediated gene expression profile. The results indicated that human MCs might modulate the immune system in a receptor-specific manner by releasing cytokines in quantitatively and qualitatively different ways.
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Article / Publication Details
Published online: August 15, 2005
Cover Date: 2005
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISBN: 978-3-8055-7948-3 (Print)
eISBN: 978-3-318-01232-3 (Online)
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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