Immunology of Pregnancy

Editor(s): Markert, U.R. (Jena)

Cytokine Regulation and Signal Transduction in Pregnancy

T Cells in Pregnancy

Piccinni M.

Author affiliations

Department of Internal Medicine, Immunoallergology Unit, University of Florence, Florence, Italy

Related Articles for ""

Markert UR (ed): Immunology of Pregnancy. Chem Immunol Allergy. Basel, Karger, 2005, vol 89, pp 3-9

Log in to MyKarger to check if you already have access to this content.


Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!


If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.

Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Complete book

  • Immediate access to all parts of this book
  • Cover-to-cover formats may be available
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restriction for personal use
read more

Pricing depends on hard-cover price


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Cytokine Regulation and Signal Transduction in Pregnancy

Published online: August 25, 2005
Cover Date: 2005

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-7970-4 (Print)
eISBN: 978-3-318-01248-4 (Online)

Abstract

Maternal tolerance of the fetal allograft could be the result of the integration of numerous mechanisms promoted by different cells present in the decidua. Decidual macrophages and dendritic cells, which are found in close association with T lymphocytes are the most potent activators of T lymphocyte responses and could play a sentinel function for the immune system, initiating antigen-specific T cell responses to fetal antigens. T cell cytokines produced in response to fetal molecules could have a role in the maintenance or in the failure of pregnancy. The levels of LIF, IL-4, IL-10 and M-CSF produced by decidual T cells of women suffering from unexplained spontaneous abortion are lower than those of normal pregnant women indicating that these cytokines may contribute to the maintenance of pregnancy. T cells from the cumulus oophorus surrounding the preimplantation embryo produce LIF and IL-4. These findings suggest that cytokines produced by maternal T cells create a suitable microenvironment for preimplantation embryo development and maintenance of pregnancy. T cell cytokine profile could be modulated by the hormones present in the microenvironment of T cells: high doses of progesterone present at fetomaternal interface and in the cumulus induce the production of IL-4 and LIF, whereas relaxin induces IFN-γ production.




Related Articles:


Article / Publication Details

First-Page Preview
Abstract of Cytokine Regulation and Signal Transduction in Pregnancy

Published online: August 25, 2005
Cover Date: 2005

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-7970-4 (Print)
eISBN: 978-3-318-01248-4 (Online)


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
TOP