American Journal of Nephrology

Original Report: Patient-Oriented, Translational Research

Comparison of Effect of Vitamin E-Coated Dialyzer and Oral Vitamin E on Hemodialysis-Induced Cu/Zn-Superoxide Dismutase

Akiyama S.a, b · Inagaki M.a · Tsuji M.a · Gotoh H.b · Gotoh T.b · Washio K.b · Gotoh Y.b · Oguchi K.a

Author affiliations

aDepartment of Pharmacology, School of Medicine, Showa University, Tokyo, and bSaiyu Soka Hospital, Saitama, Japan

Keywords: Vitamin EVitamin E-coated dialyzerCu/Zn-SODCu/Zn-SOD mRNAOxidative stress and hemodialysis

Related Articles for ""
Am J Nephrol 2005;25:500–506
https://doi.org/10.1159/000088172

Log in to MyKarger to check if you already have access to this content.




Forgot your password
Sign up to MyKarger

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more
CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!


If you would like to redeem your KAB credit, please log in.

Save over 20% compared to the individual article price.

Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates

Select
* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: March 16, 2005
Accepted: July 28, 2005
Published online: October 12, 2005
Issue release date: September – October

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN

Abstract

Background: We reported earlier that production of Cu/Zn-superoxide dismutase (SOD) increases markedly in hemodialysis patients but not in non-dialyzed chronic renal failure (CRF) patients. In this study, we compared the antioxidant effects of oral vitamin E supplementation (VE-PO) and vitamin E coating of a dialyzer (VE-BMD) by measuring increased Cu/Zn-SOD in hemodialysis patients. Methods: 31 hemodialysis patients were divided into two groups: 16 hemodialysis patients underwent usual dialysis with vitamin E supplementation 600 mg/day while 15 others were dialyzed using vitamin E-coated membrane for 6 months. Total plasma SOD activity was determined by NBT method, plasma Cu/Zn-SOD contents by ELISA and Cu/Zn-SOD mRNA in leukocytes by RT-PCR. Results: VE-PO and VE-BMD showed almost comparable effects on Cu/Zn-SOD contents and its mRNA levels in hemodialysis patients. VE-PO resulted in a progressive decrease of Cu/Zn-SOD content (p < 0.001). A comparable progressive decrease was observed also in VE-BMD (p < 0.0001). Both VE-PO and VE-BMD resulted in a progressive decrease of Cu/Zn-SOD mRNA (p < 0.01), which reached the level of non-dialyzed CRF patients.

© 2005 S. Karger AG, Basel



Related Articles:

References

  1. Harnett JD, Kent GM, Foley RN, Parfrey PS: Cardiac function and hematocrit level. Am J Kidney Dis 1995;25(suppl 1):S3–S7.
    External Resources
  2. Parfrey PS: Cardiac and cerebrovascular disease in chronic uremia. Am J Kidney Dis 1993;21:77–80.
    External Resources
  3. Maher ER, Wickens DG, Griffin JF, Kyle P, Curtis JR, Dormandy TL: Increased free-radical activity during haemodialysis? Nephrol Dial Transplant 1987;2:169–171.
    External Resources
  4. Descamps-Latscha B, Goldfarb B, Nguyen AT, Landais P, London G, Haeffner-Cavaillon N, Jacquot C, Herbelin A, Kazatchkine M: Establishing the relationship between complement activation and stimulation of phagocyte oxidative metabolism in hemodialyzed patients: A randomized prospective study. Nephron 1991;59:279–285.
    External Resources
  5. Bonomini M, Stuard S, Carreno MP, Settefrati N, Santarelli P, Haeffner-Cavaillon N, Albertazzi A: Neutrophil reactive oxygen species production during hemodialysis: Role of activated platelet adhesion to neutrophils through P-selectin. Nephron 1997;75:402–411.
    External Resources
  6. Lindner A, Charra B, Sherrard DJ, Scribner BH: Accelerated atherosclerosis in prolonged maintenance hemodialysis. N Engl J Med 1974;290:697–701.
    External Resources
  7. Ichikawa I, Kiyama S, Yoshioka T: Renal antioxidant enzymes: Their regulation and function. Kidney Int 1994;45:1–9.
    External Resources
  8. Frei B, Stocker R, Ames BN: Antioxidant defenses and lipid peroxidation in human blood plasma. Proc Natl Acad Sci USA 1988;85:9748–9752.
    External Resources
  9. Shurtz-Swirski R, Mashiach E, Kristal B, Shkolnik T, Shasha SM: Antioxidant enzymes activity in polymorphonuclear leukocytes in chronic renal failure. Nephron 1995;71:176–179.
    External Resources
  10. Bannister JV, Bannister WH, Rotilio G: Aspects of the structure, function, and applications of superoxide dismutase. CRC Crit Rev Biochem 1987;22:111–180.
    External Resources
  11. Strålin P, Karlsson K, Johansson BO, Marklund SL: The interstitium of the human arterial wall contains very large amounts of extracellular superoxide dismutase. Arterioscler Thromb Vasc Biol 1995;15:2032–2036.
    External Resources
  12. Marklund SL: Extracellular superoxide dismutase in human tissues and human cell lines. J Clin Invest 1984;74:1398–1403.
    External Resources
  13. Nakayama H, Akiyama S, Shiotani S, Gotoh H, Inagaki M, Oguchi K: Evaluation of superoxide dismutase activity in dialyzed patients by electron spin resonance spectroscopy. Am J Nephrol 2002;22:6–10.
    External Resources
  14. Akiyama S, Inagaki M, Tsuji M, Gotoh H, Gotoh T, Gotoh Y, Oguchi K: mRNA study on Cu/Zn superoxide dismutase induction by hemodialysis treatment. Nephron Clin Pract 2005;99:c107–c114.
    External Resources
  15. Islam KN, O’Byrne D, Devaraj S, Palmer B, Grundy SM, Jialal I: Alpha-tocopherol supplementation decreases the oxidative susceptibility of LDL in renal failure patients on dialysis therapy. Atherosclerosis 2000;150:217–224.
    External Resources
  16. Pastor MC, Sierra C, Bonal J, Teixido J: Serum and erythrocyte tocopherol in uremic patients: effect of hemodialysis versus peritoneal dialysis. Am J Nephrol 1993;13:238–243.
    External Resources
  17. Cristol JP, Bosc JY, Badiou S, Leblanc M, Lorrho R, Descomps B, Canaud B: Erythropoietin and oxidative stress in haemodialysis: beneficial effects of vitamin E supplementation. Nephrol Dial Transplant 1997;12:2312–2317.
    External Resources
  18. Schiecke G, Gwinner W, Radermacher J, Bahlmann J, Lonnemann G: Long-term effects of vitamin E-bonded dialysis membrane on mononuclear cell activation, malondialdehyde generation and endothelial function in ESRD patients. Contrib Nephrol. Basel, Karger, 1999, vol 127, pp 243–250.
    External Resources
  19. Sanaka T, Omata M, Nishimura H, Shinobe M, Higuchi C: Suppressive effects of vitamin E-coated dialysis membrane on hemodialysis-induced neutrophil activation. Contrib Nephrol. Basel, Karger, 1999, vol 127, pp 261–268.
    External Resources
  20. Shimazu T, Kondo S, Toyama K, Komurai M, Ohminato M, Yasuda T, Sato T, Maeba T, Maruyama H, Owada S, Ishida M: Effect of vitamin E-modified regenerative cellulose membrane on neutrophil superoxide anion radical production and lipid peroxidation. Contrib Nephrol. Basel, Karger, 1999, vol 127, pp 251–260.
    External Resources
  21. Oberley LW, Spitz DR: Assay of superoxide dismutase activity in tumor tissue. Methods Enzymol 1984;105:457–464.
    External Resources
  22. Cachia O, Leger CL, Boulot P, Vernet MH, Michel F, Crastes de Paulet A, Descomps B: Red blood cell vitamin E concentrations in fetuses are related to but lower than those in mothers during gestation. A possible association with maternal lipoprotein (a) plasma levels. Am J Obstet Gynecol 1995;173:42–51.
    External Resources
  23. Friedman EA, Lundin AP: Outcome and complications of chronic hemodialysis; in Shrier RW, Gottschalk CW (eds): Diseases of the Kidney. Boston, Little Brown, 1988, vol 3, p 3069.
  24. Lindner A, Charra B, Sherrard DJ, Scribner BH: Accelerated atherosclerosis in prolonged maintenance hemodialysis. N Engl J Med 1974;28:697–701.
    External Resources
  25. Warner BB, Stuart L, Gebb S, Wispé JR: Redox regulation of manganese superoxide dismutase. Am J Physiol 1996;271:L150–L158.
  26. Lin YF, Chang DM, Shaio MF, Lu KC, Chyr SH, Li BL, Sheih SD: Cytokine production during hemodialysis: effects of dialytic membrane and complement activation. Am J Nephrol 1996;16:293–299.
    External Resources
  27. Haeffner-Cavaillon N, Jahns G, Poignet JL, Kazatchkine MD: Induction of interleukin-1 during hemodialysis. Kidney Int 1993;43(suppl 39):S139–S143.
  28. Pertosa G, Gesualdo L, Tarantino EA, Ranieri E, Bottalico D, Schena FP: Influence of hemodialysis on interleukin-6 production and gene expression by peripheral blood mononuclear cells. Kidney Int 1993;43(suppl 39):S149–S153.
  29. Luger A, Kovarik J, Stummvoll HK, Urbanska A, Luger TA: Blood-membrane interaction in hemodialysis leads to increased cytokine production. Kidney Int 1987;32:84–88.
    External Resources
  30. Niwa Y, Ozaki Y, Kanoh T, Akamatsu H, Kurisaka M: Role of cytokines, tyrosine kinase, and protein kinase C on production of superoxide and induction of scavenging enzymes in human leukocytes. Clin Immunol Immunopathol 1996;79:303–313.
    External Resources
  31. Uchimura K, Nagasaka A, Hayashi R, Makino M, Nagata M, Kakizawa H, Kobayashi T, Fujiwara K, Kato T, Iwase K, Shinohara R, Kato K, Itoh M: Changes in superoxide dismutase activities and concentrations and myeloperoxidase activities in leukocytes from patients with diabetes mellitus. J Diabetes Complications 1999;13:264–270.
    External Resources
  32. Marklund SL: Superoxide dismutase in human tissues, cells, and extracellular fluids: clinical implications; in Johnson JE et al (eds): Free Radicals, Aging, and Degenerative Diseases. New York, Liss, 1986, pp 509–526.
  33. Galli F, Varga Z, Balla J, Ferraro B, Canestrari F, Floridi A, Kakuk G, Buoncristiani U: Vitamin E, lipid profile, and peroxidation in hemodialysis patients. Kidney Int Suppl 2001;78:S148–S154.
    External Resources
  34. Boaz M, Smetana S, Weinstein T, Matas Z, Gafter U, Iaina A, Knecht A, Weissgarten Y, Brunner D, Fainaru M, Green MS: Secondary prevention with antioxidants of cardiovascular disease in end-stage renal disease (SPACE): randomised placebo-controlled trial. Lancet 2000;356:1213–1218.
    External Resources
  35. Galli F, Rovidati S, Chiarantini L, Campus G, Canestrari F, Buoncristiani U: Bioreactivity and biocompatibility of a vitamin E-modified multilayer hemodialysis filter. Kidney Int 1998;54:580–589.
    External Resources
  36. Hultqvist M, Hegbrant J, Nilsson-Thorell C, Lindholm T, Nilsson P, Linden T, Hultqvist-Bengtsson U: Plasma concentrations of vitamin C, vitamin E and/or malondialdehyde as markers of oxygen free radical production during hemodialysis. Clin Nephrol 1997;47:37–46.
    External Resources
  37. Paul JL, Sall ND, Soni T, Poignet JL, Lindenbaum A, Man NK, Moatti N, Raichvarg D: Lipid peroxidation abnormalities in hemodialyzed patients. Nephron 1993;64:106–109.
    External Resources
  38. Triolo L, Lippa S, Oradei A, De Sole P, Mori R: Serum coenzyme Q10 in uremic patients on chronic hemodialysis. Nephron 1994;66:153–156.
    External Resources

Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: March 16, 2005
Accepted: July 28, 2005
Published online: October 12, 2005
Issue release date: September – October

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Article Tools
Article Details

2005, Vol.25, No. 5

September – October

Article

Recommend This
TOP