Pathophysiology of Haemostasis and Thrombosis

 
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Mathematical Modeling and Computer Simulation in Blood Coagulation

Ataullakhanov F.I.a, b, c · Panteleev M.A.a

Author affiliations

aLaboratory of Physical Biochemistry of Blood, National Research Center for Hematology, Russian Academy of Medical Sciences, Moscow, bLaboratory of Metabolic Modeling and Bioinformatics, Institute of Theoretical and Experimental Biophysics, Pushchino, Moscow Region, and cFaculty of Physics, Moscow State University, Leninskie Gory, Moscow, Russia

Corresponding Author

F.I. Ataullakhanov

Laboratory of Physical Biochemistry of Blood, National Research Center for Hematology

Russian Academy of Medical Sciences, Novozykovskii pr. 4a

Moscow 125167 (Russia)

Tel. +7 095 212 55 31, Fax +7 095 212 88 70, E-Mail fazly@hc.comcor.ru

Keywords: Blood coagulationMathematical modelingComputer simulationThrombin generationBlood flowEnzyme cascadesMetabolic control

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Pathophysiol Haemos Thromb 2005;34:60–70
https://doi.org/10.1159/000089927

Abstract

Over the last two decades, mathematical modeling has become a popular tool in study of blood coagulation. The in silico methods were able to yield interesting and significant results in the understanding of both individual reaction mechanisms and regulation of large sections of the coagulation cascade. The objective of this paper is to review the development of theoretical research in hemostasis and thrombosis, to summarize the main findings, and outline problems and possible prospects in the use of mathematical modeling and computer simulation approaches. This review is primarily focused on the studies dealing with: (1) the membrane-dependent reactions of coagulation; (2) regulation of the coagulation cascade, including effects of positive and negative feedback loops, diffusion of coagulation factors, and blood flow.

© 2005 S. Karger AG, Basel



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Published online: January 26, 2006
Issue release date: January 2006

Number of Print Pages: 11
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ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

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