Association of the Phe206Leu Allele of the L-Selectin Gene with Coronary Artery DiseaseHajilooi M.a · Tajik N.b · Sanati A.d · Eftekhari H.e · Massoud A.c
Departments of Immunology,aMolecular Medicine Research Center, Hamedan University of Medical Sciences, Hamedan, bIran University of Medical Sciences and cTehran University of Medical Sciences, Tehran, and dDepartment of Cardiology, Tehran University of Medical Sciences, Tehran, Iran; eDepartment of Internal Medicine, University of Texas-Houston, Houston, Tex., USA
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Background and Aims: The aim of this study was to assess the association between the L-selectin Phe206Leu polymorphism and coronary artery disease. Methods: A total of 322 patients (221 men and 101 women) with coronary artery disease in one or more vessels documented by angiography were studied; 157 subjects (85 men and 72 women) without atherosclerosis were included as controls. All subjects were genotyped for the L-selectin Phe206Leu gene polymorphism using polymerase chain reaction with sequence-specific primer (PCR-SSP). To assess disease severity, all patients were classified by numbers of coronary arteries with 50% stenosis. Results: A significantly increased frequency of the 206Leu mutant allele was observed in patients with coronary artery disease compared to the controls. The 206Leu allele frequency occurred in 42% of the patients with coronary artery disease compared to 30% of the controls (p < 0.009). No association was found between the severity of coronary artery disease and the L-selectin Phe206Leu polymorphism. Conclusion: Our findings suggest that carriage of L-selectin 206Leu mutant allele could contribute to susceptibility of Iranian individuals to contracting coronary artery disease.
© 2006 S. Karger AG, Basel
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