Neurodegenerative Diseases
Special Topic Section: Immunotherapies and Related Strategies in Alzheimer’s ...
Clinical Observations with AN-1792 Using TAPIR AnalysesHock C. · Nitsch R.M.Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
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Neurodegenerative Dis 2005;2:273–276
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Article / Publication Details
First-Page Preview
Published online: February 22, 2006
Issue release date: February 2006
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1
ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)
For additional information: https://www.karger.com/NDD
Abstract
Clinical observations with AN-1792 using tissue amyloid plaque immunoreactivity (TAPIR) analyses established for the first time evidence in humans that antibodies against β-amyloid-related epitopes are capable of slowing progression in Alzheimer’s disease. Antibodies derived upon TAPIR assay selection may specifically target the pathologic neoepitopes of aggregated Aβ species present in amyloid plaques and some of their aggregated, protofibrillar and low molecular weight oligomeric precursors. We briefly summarize here how the proof of concept was established and why it provides the basis for a potential cure for Alzheimer’s disease.
© 2005 S. Karger AG, Basel
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Article / Publication Details
First-Page Preview
Published online: February 22, 2006
Issue release date: February 2006
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1
ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)
For additional information: https://www.karger.com/NDD
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