International Archives of Allergy and Immunology
Original Paper
Total IgE Levels Do Not Change 1 Year after Endoscopic Sinus Surgery in Patients with Chronic RhinosinusitisLal D. · Baroody F.M. · Weitzel E.K. · deTineo M. · Naclerio R.M.Section of Otolaryngology-Head and Neck Surgery, Pritzker School of Medicine, University of Chicago, Chicago, Ill., USA
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Article / Publication Details
Received: May 23, 2005
Accepted: October 06, 2005
Published online: February 01, 2006
Issue release date: January 2006
Number of Print Pages: 3
Number of Figures: 2
Number of Tables: 0
ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)
For additional information: https://www.karger.com/IAA
Abstract
Background: Total IgE levels positively correlate with the amount of mucosal thickening on sinus CT scans. Our objective was to investigate whether the levels of total serum IgE decreased 1 year after endoscopic sinus surgery in patients with chronic rhinosinusitis, suggesting that the total IgE was influenced by the sinus disease. Methods: 55 patients about to undergo endoscopic sinus surgery for chronic rhinosinusitis were enrolled in a prospective clinical study. All patients had preoperative sinus computerized tomography (CT) scans and levels of total serum IgE measured before surgery and 1 year postoperatively. Results: Preoperative total IgE levels showed a significant correlation with the extent of disease on sinus CT (rs = 0.413, p = 0.002). Total serum IgE levels did not show any statistically significant change from the preoperative values when measured 1 year postoperatively (324.25 ± 217.30 ng/ml vs. 326.35 ± 204.50 ng/ml; p = 0.61). Conclusions: The levels of total serum IgE do not change after sinus surgery for chronic rhinosinusitis. IgE levels in chronic rhinosinusitis may reflect a systemic factor in disease pathogenesis, and are probably not related to the amount of local inflammation within the sinuses.
© 2006 S. Karger AG, Basel
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References
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Naclerio RM, Baroody F: Understanding the inflammatory processes in upper allergic airway disease and asthma. J Allergy Clin Immunol 1998;101:S345–S351.
External Resources
- Newman LJ, Platts-Mills TAE, Phillips CD, et al: Chronic sinusitis: relationship of computed tomographic findings to allergy, asthma and eosinophilia. JAMA 1994;271:363–367.
- Baroody FM, Suh S, Naclerio RM: Total IgE serum levels correlate with sinus mucosal thickness on computerized tomography scans. J Allergy Clin Immunol 1997;100:563–568.
- Lund VJ, Mackay IS: Staging in rhinosinusitis. Rhinology 1993;31:183–184.
- Konduri KS, Nandedkar S, Duzgunzes N, et al: Efficacy of liposomal budesonide in experimental asthma. J Allergy Clin Immunol 2003;111:321–327.
- Schubert MS, Goetz DW: Evaluation and treatment of allergic fungal sinusitis. II. Treatment and follow-up. J Allergy Clin Immunol 1998;102:395–402.
- Kennedy DW: Prognostic factors, outcomes and staging in ethmoid sinus surgery. Laryngoscope 1992;102:1–18.
Article / Publication Details
Received: May 23, 2005
Accepted: October 06, 2005
Published online: February 01, 2006
Issue release date: January 2006
Number of Print Pages: 3
Number of Figures: 2
Number of Tables: 0
ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)
For additional information: https://www.karger.com/IAA
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